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首页> 外文期刊>Retina >ACCELERATED REPERFUSION OF POORLY PERFUSED RETINAL AREAS IN CENTRAL RETINAL ARTERY OCCLUSION AND BRANCH RETINAL ARTERY OCCLUSION AFTER A SHORT TREATMENT WITH ENHANCED EXTERNAL COUNTERPULSATION.
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ACCELERATED REPERFUSION OF POORLY PERFUSED RETINAL AREAS IN CENTRAL RETINAL ARTERY OCCLUSION AND BRANCH RETINAL ARTERY OCCLUSION AFTER A SHORT TREATMENT WITH ENHANCED EXTERNAL COUNTERPULSATION.

机译：在短期内用增强的外部对症治疗后，在视网膜中央动脉阻塞和视网膜分支动脉阻塞中灌注不良的视网膜区域，加快了再灌注。

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BACKGROUND:: To date, no satisfactory therapy has become available for patients with acute central retinal artery occlusion (CRAO) or branch retinal artery occlusion (BRAO). Enhanced external counterpulsation (EECP) is a new noninvasive procedure that increases perfusion of inner organs. In the current study, the authors measured the impact of EECP on reperfusion in ischemic retinal tissue. METHODS:: In a prospective, randomized study, 20 patients with CRAO or BRAO were included. Ten patients were given hemodilution therapy and 2 hours of EECP, and 10 patients were given regular hemodilution therapy only. Quantification of changes in retinal perfusion was carried out by means of scanning laser Doppler flowmetry (in arbitrary units). RESULTS:: Enhanced external counterpulsation caused no observable adverse events. A significant increase in perfusion occurred immediately after EECP in the ischemic retinal areas (57 +/- 19 arbitrary units versus 99 +/- 14 arbitrary units). In contrast, no change was measured in the group not treated with EECP (83 +/- 19 arbitrary units versus 89 +/- 44 arbitrary units). Forty-eight hours later, a significant increase in perfusion could be shown in the ischemic retina of both groups, and no significant difference of perfusion was found between the two groups any longer. CONCLUSION:: The current study suggests that EECP could be a clinically useful and safe procedure in patients with CRAO or BRAO to accelerate recovery of perfusion in ischemic retinal areas.
机译：背景：迄今为止，尚无令人满意的疗法可用于患有急性中央视网膜动脉阻塞（CRAO）或视网膜分支动脉阻塞（BRAO）的患者。增强的外部反搏（EECP）是一种新的非侵入性程序，可增加内部器官的灌注。在当前的研究中，作者测量了EECP对缺血性视网膜组织再灌注的影响。方法：在一项前瞻性随机研究中，纳入了20例CRAO或BRAO患者。 10例患者接受了血液稀释疗法和EECP 2小时，而10例患者仅接受了常规血液稀释疗法。通过扫描激光多普勒血流仪（以任意单位）来量化视网膜灌注的变化。结果：增强的外部反搏没有引起可观察到的不良事件。 EECP后立即在缺血性视网膜区域灌注显着增加（57 +/- 19任意单位对99 +/- 14任意单位）。相反，在未用EECP治疗的组中未测量到变化（83 +/- 19任意单位与89 +/- 44任意单位）。 48小时后，两组缺血性视网膜的灌注均显着增加，并且两组之间的灌注均无明显差异。结论：当前研究表明，EECP对于CRAO或BRAO患者可能是一种临床上有用且安全的方法，可加快缺血性视网膜区域的灌注恢复。

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