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首页> 外文期刊>Retina >Plus disease diagnosis in retinopathy of prematurity: Vascular tortuosity as a function of distance from optic disk
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Plus disease diagnosis in retinopathy of prematurity: Vascular tortuosity as a function of distance from optic disk

机译：早产儿视网膜病变中的疾病诊断：血管曲折度与视盘距离的函数

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PURPOSE:: To examine vascular tortuosity as a function of distance from the optic disk in infants with retinopathy of prematurity. METHODS:: Thirty-four wide-angle retinal images from infants with retinopathy of prematurity were reviewed by 22 experts. A reference standard for each image was defined as the diagnosis (plus vs. not plus) given by the majority of experts. Tortuosity, defined as vessel length divided by straight line distance between vessel end points, was calculated as a function of distance from the disk margin for arteries and veins using computer-based methods developed by the authors. RESULTS:: Mean cumulative tortuosity increased with distance from the disk margin, both in 13 images with plus disease (P = 0.007 for arterial tortuosity [n = 62 arteries], P < 0.001 for venous tortuosity [n = 58 veins] based on slope of best fit line by regression), and in 21 images without plus disease (P < 0.001 for arterial tortuosity [n = 94 arteries], P <0 .001 for venous tortuosity [n = 85 veins]). Images with plus disease had significantly higher vascular tortuosity than images without plus disease (P < 0.05), up to 7.0 disk diameters from the optic disk margin. CONCLUSION:: Vascular tortuosity was higher peripherally than centrally, both in images with and without plus disease, suggesting that peripheral retinal features may be relevant for retinopathy of prematurity diagnosis.
机译：目的：：检查早产儿视网膜病变婴儿的血管曲折度与距视盘的距离的关系。方法：22位专家对来自早产儿视网膜病变的婴儿的34张广角视网膜图像进行了审查。每个图像的参考标准被定义为大多数专家给出的诊断（加或不加）。使用作者开发的基于计算机的方法，将曲折度定义为血管长度除以血管端点之间的直线距离，将其作为距动脉和静脉的椎间盘边缘距离的函数。结果：在13例伴有疾病的图像中，平均累积曲折度随着距磁盘边缘的距离而增加（动脉曲折度[P = 0.007 [n = 62动脉]，静脉曲折度[n = 58静脉] P = 0.001）并通过回归分析得出最佳拟合线），并在21幅无疾病的图像中（动脉曲折性P <0.001 [n = 94条动脉]，静脉曲折度P <0.001 [n = 85条静脉]）。伴有疾病的图像比不伴疾病的图像具有更高的血管曲折度（P <0.05），从视盘边缘到视盘直径最大为7.0。结论：无论有无疾病影像，外周血管曲折度均高于中央，提示外周视网膜特征可能与早产儿视网膜病变有关。

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