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Developmental decisions: Balancing genetics and the environment by C. elegans

机译：发展决策：秀丽隐杆线虫平衡遗传和环境

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摘要

The small nematode C. elegans is characterized by developing through a highly coordinated, reproducible cell lineage that serves as the basis of many studies focusing on the development of multi-lineage organisms. Indeed, the reproducible cell lineage enables discovery of developmental defects that occur in even a single cell. Only recently has attention been focused on how these animals modify their genetically programmed cell lineages to adapt to altered environments. Here, we summarize the current understanding of how C. elegans responds to food deprivation by adapting their developmental program in order to conserve energy. In particular, we highlight the AMPK-mediated and insulinlike growth factor signaling pathways that are the principal regulators of induced cell cycle quiescence.
机译：小型线虫秀丽隐杆线虫的特征是通过高度协调，可再现的细胞谱系发育，这是许多专注于多谱系生物发展的研究的基础。实际上，可重现的细胞谱系能够发现甚至在单个细胞中也会发生的发育缺陷。直到最近，注意力都集中在这些动物如何修改其遗传程序化细胞谱系以适应变化的环境上。在这里，我们总结了当前对秀丽隐杆线虫如何通过适应其发展计划以节约能源来应对食物匮乏的理解。特别是，我们重点介绍了AMPK介导的胰岛素样生长因子信号通路，它们是诱导细胞周期静止的主要调节因子。

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