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首页> 外文期刊>Retina >A randomized trial comparing intravitreal triamcinolone and focal/grid photocoagulation for diabetic macular edema: baseline features.
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A randomized trial comparing intravitreal triamcinolone and focal/grid photocoagulation for diabetic macular edema: baseline features.

机译：比较玻璃体内曲安奈德和局灶/网格光凝治疗糖尿病性黄斑水肿的随机试验：基线特征。

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PURPOSE: To compare baseline demographic, systemic, and ocular characteristics within age and racial subgroups among participants in this Diabetic Retinopathy Clinical Research Network clinical trial and to compare this cohort with other cohorts enrolled in phase 3 clinical trials for diabetic retinopathy. METHODS: Thirty-six month, randomized, controlled, multicenter clinical trial of 693 participants with diabetic macular edema enrolled at 88 clinical sites in the United States. Participants were categorized into self-reported race/ethnicity subgroups and into one of three age groups: 18 to 60, 60 to 70, and 70 and older. RESULTS: Mean age of participants was 63 years, 72% were white, and median visual acuity letter score was 62 (approximately 20/63). No substantial difference was identified between racial subgroups for any baseline variable. Older participants were more likely to have Type 2 diabetes mellitus and longer duration disease. The most frequent levels of diabetic retinopathy among840 study eyes were moderate (level 43) to moderately severe (level 47) nonproliferative disease. CONCLUSION: While the racial composition of this cohort does not differ from other cohorts in large phase 3 trials that have evaluated participants with diabetic retinopathy, the inclusion of many subjects over age 70 and a better level of glycemic control are distinguishing features.
机译：目的：比较该糖尿病视网膜病变临床研究网络临床试验参与者的年龄和种族亚组内的基线人口统计学，全身和眼部特征，并将该队列与参加糖尿病视网膜病变三期临床试验的其他队列进行比较。方法：在美国88个临床地点进行的为期36个月的随机，对照，多中心临床试验，其中包括693名糖尿病性黄斑水肿参与者。参与者分为自我报告的种族/族裔亚组和三个年龄组之一：18至<60、60至<70和70岁以上。结果：受试者的平均年龄为63岁，白人为72％，视力字母中位数为62（大约20/63）。在任何基线变量的种族亚组之间均未发现实质性差异。年龄较大的参与者更有可能患2型糖尿病和病程较长。在840只研究眼中，糖尿病性视网膜病变的最常见水平是中度（43级）至中度（47级）非增生性疾病。结论：尽管该人群的种族组成与大型3期试验（评估糖尿病性视网膜病参与者）的其他人群并无不同，但纳入许多70岁以上的受试者和更好的血糖控制水平是其显着特征。

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