BRAF mutation: A double-edged sword in epigenetic alterations?

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BRAF mutation: A double-edged sword in epigenetic alterations?

机译：BRAF突变：表观遗传变异中的一把双刃剑？

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BRAF is one of the most frequently mutated oncogenes in human cancers. Approximately 40-60% of melanomas and papillary thyroid carcinomas harbor a BRAF mutation. BRAF mutations predominantly take place in exon 15, best exemplified by the substitution of thymine at nucleic acid 1799 with adenine, leading to the conversion of valine at residue 600 to glutamine (V600E). B-Raf kinase and MAP kinase pathway activation induces the expression of many genes through AP-1 and other transcription factors.

机译：BRAF是人类癌症中最常见的突变癌基因之一。大约40-60％的黑色素瘤和甲状腺乳头状癌带有BRAF突变。 BRAF突变主要发生在第15外显子上，最典型的例子是核酸1799中的胸腺嘧啶被腺嘌呤取代，导致残基600上的缬氨酸转化为谷氨酰胺（V600E）。 B-Raf激酶和MAP激酶途径的激活通过AP-1和其他转录因子诱导许多基因的表达。

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《Cell cycle》 |2012年第3期|共2页
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正文语种 eng
中图分类细胞生物学;
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1. BRAF mutation: A double-edged sword in epigenetic alterations? [J] . XuX. Cell cycle . 2012,第3期

机译：BRAF突变：表观遗传变异中的一把双刃剑？
2. Functional Analyses of Mutations in Receptor Tyrosine Kinase Genes in Non-Small Cell Lung Cancer: Double-Edged Sword of DDR2 [J] . Terashima Masato, Togashi Yosuke, Sato Katsuaki, Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第14期

机译：非小细胞肺癌受体酪氨酸激酶基因突变的功能分析：DDR2的双刃剑。
3. Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword [J] . Jaszczur Malgorzata, Bertram Jeffrey G., Robinson Andrew, Biochemistry . 2016,第16期

机译：突变或更差：SOS DNA聚合酶V合成的低保真DNA是严格管制的双刃剑
4. The Double-Edged Sword of Automating Personalized Interventions in Makerspaces: An Exploratory Study of Potential Benefits and Drawbacks [C] . Edwin Chng, Sofya Zeylikman, Bertrand Schneider International Conference on Artificial Intelligence in Education . 2020

机译：在Makerspace中自动执行个性化干预的双刃剑：对潜在收益和弊端的探索性研究
5. NRAS and BRAF mutations in primary cutaneous melanoma: A comparison of mutation rates between radial and vertical growth phases in individual tumors. [D] . Greene, Victoria R. 2007

机译：原发性皮肤黑素瘤中的NRAS和BRAF突变：单个肿瘤在径向和垂直生长期之间的突变率比较。
6. Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations [O] . Takeshi Sawada, Eiichiro Yamamoto, Hiro-o Yamano, 2016

机译：评估包含BRAF突变的早期大肠病变的表观遗传学变化
7. Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword [O] . Malgorzata Jaszczur, Jeffrey G. Bertram, Andrew Robinson, 2016

机译：更差或更好的突变：SOS DNA聚合酶V的低保真DNA合成是紧密调节的双刃剑

BRAF mutation: A double-edged sword in epigenetic alterations?

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