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首页> 外文期刊>Respiratory medicine >Inhalation of menthol reduces capsaicin cough sensitivity and influences inspiratory flows in chronic cough
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Inhalation of menthol reduces capsaicin cough sensitivity and influences inspiratory flows in chronic cough

机译：吸入薄荷醇可降低辣椒素的咳嗽敏感性，并影响慢性咳嗽的吸气流量

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Introduction: Chronic cough is a common clinical problem and there is a shortage of effective treatments for it. Within the group of transient receptor potential ion channels a receptor for the cooling substance menthol has been identified. This study aimed to assess whether pre-inhalation of dissolved, nebulised menthol could increase capsaicin cough thresholds and influence spirometric values. Methods: Fourteen patients with chronic cough and airway sensitivity to environmental irritants and 15 control subjects were tested on three occasions. Each one inhaled a 1 mL of nebulised menthol solution of 0.5% or 1% or placebo (saline with 0.05% menthol) at each visit in a randomized and double-blind order. They were then provoked by capsaicin inhalation. Results: Patients' cough thresholds differed significantly from the controls' on all three provocations (P < 0.0001). After inhalation of 1% menthol, the patients' cough thresholds were significantly higher (P < 0.02) compared to after placebo inhalation and to after 0.5% menthol inhalation (P < 0.05). The patients' peak inspiratory flows were significantly reduced after inhalation of the placebo (saline) (P < 0.05) but not after inhalation of 0.5% or 1% menthol. Forced inspiratory flows 50% were lowered after inhalation of placebo and of 0.5% menthol (P < 0.05) but not after 1% menthol. Among the controls, forced inspiratory flows 50% were lowered after only placebo inhalation (P < 0.05). Conclusions: In patients with chronic cough, pre-inhalation of menthol reduces cough sensitivity to inhaled capsaicin and influences inspiratory flows. The findings may provide scientific support for the common practice of using menthol as a reliever for variant airway discomfort. The use of menthol in different cigarette brands could be questioned since it could conceal the natural irritation following smoking. ? 2012 Published by Elsevier Ltd.
机译：简介：慢性咳嗽是一个常见的临床问题，缺乏有效的治疗方法。在瞬态受体势离子通道组中，已经确定了冷却物质薄荷醇的受体。这项研究旨在评估预先吸入溶解的雾化薄荷醇是否可以增加辣椒素的咳嗽阈值并影响肺活量测定值。方法：对14名慢性咳嗽和气道对环境刺激物敏感的患者和15名对照受试者进行了3次测试。每次随访时，每位患者均以随机和双盲的顺序吸入1 mL 0.5％或1％的雾化薄荷醇溶液或安慰剂（含0.05％薄荷醇的盐水）。然后吸入辣椒素激怒了他们。结果：在所有三个刺激中，患者的咳嗽阈值均与对照组的差异显着（P <0.0001）。吸入1％薄荷醇后，患者的咳嗽阈值明显高于安慰剂吸入后和0.5％薄荷醇吸入后的咳嗽阈值（P <0.05）。吸入安慰剂（盐水）后，患者的峰值吸气流量显着降低（P <0.05），但吸入0.5％或1％的薄荷醇后并未消失。吸入安慰剂和0.5％薄荷醇后，强制吸气流量降低50％（P <0.05），但加入1％薄荷醇后不降低。在对照组中，仅安慰剂吸入后强迫吸气量降低了50％（P <0.05）。结论：在慢性咳嗽患者中，薄荷醇的预先吸入降低了咳嗽对吸入辣椒素的敏感性并影响了吸气量。这些发现可能为使用薄荷醇缓解气道不适的常用方法提供科学依据。薄荷醇在不同卷烟品牌中的使用可能会受到质疑，因为它可以掩盖吸烟后的自然刺激。 ？ 2012年由Elsevier Ltd.出版

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