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首页> 外文期刊>Radiation and Environmental Biophysics >Is there reliable experimental evidence for different dicentric yields in human lymphocytes produced by mammography X-rays free-in-air and within a phantom?
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Is there reliable experimental evidence for different dicentric yields in human lymphocytes produced by mammography X-rays free-in-air and within a phantom?

机译：是否存在可靠的实验证据，证明了在空气中和幻像内进行乳房X射线摄影所产生的人类淋巴细胞的不同双中心产量？

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摘要

We examined the production of dicentrics in human lymphocytes irradiated with 29 kV X-rays to a depth of 13.5 mm in a PMMA phantom.For these irradiation conditions,which are appropriate for the diagnostic application of mammography X-rays,a coefficient a of (5.88+-0.66)xl0~(-2) Gy~(-1) of the linear quadratic dose-response relationship was determined.This value does not differ significantly from the coefficient a of (6.55+-0.97)xl0~(-2) Gy~(-1) obtained earlier for a free-in-air set-up using blood of the same donor.The results are interpreted in terms of both the energy distributions of the photon fluence of mammography X-rays free-in-air and those in the PMMA phantom.Based on earlier results of experiments with monochromatic X-rays in the energy range 1.83-40 keV (completed here by an additional measurement at 25 keV),a fit function alpha(E) to the measured a coefficients as a function of the energy E of monochromatic X-rays was used to calculate weighted mean values a for both the mammography X-ray spectra free-in-air and in the phantom.As a result,weighted mean values of (4.9+-1.0)x 10~(-2)Gy~(-1) and (4.5+-1.0)xl0~(-2) Gy~(-1) were obtained,respectively.Although the measured a coefficients for mammography X-rays appear to be systematically higher than those calculated as weighted mean values a,it can be concluded that the modification of the mammography X-ray spectrum to a depth of 13.5 mm in a PMMA phantom compared with the free-in-air spectrum has no significant influence on the dicentric yields in human lymphocytes.
机译：我们检查了在PMMA体模中用29 kV X射线辐照至13.5 mm深度的人淋巴细胞中双着丝粒的产生情况。对于这些辐照条件，这些条件适合于X射线摄影的X射线诊断学应用，系数a为（确定了线性二次剂量-反应关系的5.88 + -0.66）xl0〜（-2）Gy〜（-1），该值与（6.55 + -0.97）xl0〜（-2）的系数a没有显着差异）较早获得的Gy〜（-1），用于使用同一供体的血液进行的自由空气设置。结果以乳腺X射线自由射线的光子注量的能量分布来解释。空气和PMMA幻影中的那些。基于能量范围为1.83-40 keV的单色X射线实验的早期结果（此处通过25 keV的附加测量完成），对被测物体的拟合函数alpha（E）系数作为单色X射线能量E的函数，用于计算两个射线的加权平均值a空气中和幻影中的X射线摄影X射线谱图，结果是（4.9 + -1.0）x 10〜（-2）Gy〜（-1）和（4.5 + -1.0）xl0的加权平均值尽管分别获得了〜（-2）Gy〜（-1）。尽管所测量的X线摄影X射线系数似乎比加权平均值a所计算的X射线系统性更高，但可以得出结论：与自由光谱相比，PMMA体模中X射线光谱的深度为13.5毫米，对人淋巴细胞的双着丝粒产量没有重大影响。

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