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首页> 外文期刊>Cell cycle >Dynamics of chromatin during the repair of DNA double-strand breaks.
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Dynamics of chromatin during the repair of DNA double-strand breaks.

机译:DNA双链断裂修复过程中染色质的动力学。

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摘要

Double strand breaks (DSBs) are arguably the most deleterious DNA lesion that a cell can sustain, and defects in the ability to detect and repair these breaks result in increased genomic instability and have been causatively linked to cancer. The repair of DNA DSBs must occur in the context of chromatin, and there is increasing evidence that the modulation of chromatin plays an integral role in the DNA DSB repair process. Here, we summarize a number of key findings, largely from studies performed in budding yeast, highlighting the role of chromatin in DNA DSB responses.
机译:双链断裂(DSB)可以说是细胞可以维持的最有害的DNA损伤,检测和修复这些断裂的能力缺陷导致基因组不稳定增加,并且与癌症具有因果关系。 DNA DSB的修复必须在染色质的背景下进行,并且越来越多的证据表明,染色质的调节在DNA DSB修复过程中起着不可或缺的作用。在这里,我们总结了许多关键发现,这些发现主要来自在发芽酵母中进行的研究,突出了染色质在DNA DSB反应中的作用。

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