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The role of SHIP in cytokine-induced signaling

机译：SHIP在细胞因子诱导信号传导中的作用

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摘要

The phosphatidylinositol (PI)-3 kinase (PI3K0 pathway plays a central role in regulating many biological processes via the generation of the key second messenger PI-3,4,5-trisphosphate (PI-3,4,5-P_3). this membrane-associated phospholipid, which is rapidly, albeit transiently, synthesized from PI-4,5-P_2 by PI3K in response to a diverse array of extracellular stimuli, attracts pleckstrin homology (PH) domain-containing proteins to membranes to mediate its many effects. To ensure that the activation of this pathway is appropriately suppressed/terminated, the ubiquitously expressed tumor suppressor PTEN hydrolyzes PI-3,4,5-P_3 back to PI-4,5-P_2 while the 145-kDa hemopoietic-restricted SH2-containing inositol 5'-phosphatase, SHIP (also known as SHIP1), the 104-kDa stem cell-restricted SHIP (sSHIP) and the more widely expressed 150-kDa SHIP2 hydrolyze PI-3,4,5-P_3 to PI-3,4-P_2. In this review we will concentrate on the properties of the three SHIPs, with special emphasis being placed on the role that SHIP play in cytokine-induced signaling.
机译：磷脂酰肌醇（PI）-3激酶（PI3K0途径在关键的第二信使PI-3,4,5-三磷酸（PI-3,4,5-P_3）的产生中在调节许多生物过程中起着重要作用。膜相关磷脂是PI3K由PI-4,5-P_2迅速响应合成的，它是由PI3K响应各种细胞外刺激而快速合成的，它将含膜蛋白（PHeck）同源性（PH）域的蛋白质吸引到膜上，以介导其多种作用。为了确保适当抑制/终止该途径的激活，普遍表达的肿瘤抑制因子PTEN将PI-3,4,5-P_3水解回PI-4,5-P_2，而145kDa造血受限的SH2-含有肌醇5'-磷酸酶，SHIP（也称为SHIP1），104 kDa干细胞限制性SHIP（sSHIP）和表达更广泛的150 kDa SHIP2将PI-3、4、5-P_3水解为PI-3 ，4-P_2。在这次审查中，我们将重点介绍三个SHIP的属性，特别着重于SHIP在细胞因子诱导的信号传导中发挥的作用。

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