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首页> 外文期刊>Review in aquaculture >Virulence mechanisms of bacterial aquaculture pathogens and antivirulence therapy for aquaculture
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Virulence mechanisms of bacterial aquaculture pathogens and antivirulence therapy for aquaculture

机译：细菌性水产养殖病原体的毒力机理和水产养殖的抗毒力治疗

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摘要

Although aquaculture continues to be the fastest-growing food-producing industry worldwide, the sector faces important challenges with respect to controlling infectious diseases. Indeed, the frequent use of antibiotics, which are traditionally the most important line of defence against bacterial disease, has raised problems related to the development and spread of resistance. As a result, we currently are in a race to develop novel therapeutics that should allow us to continue controlling bacterial disease in the future. In this respect, scientific progress of the past years has allowed us to start understanding the mechanisms by which bacterial pathogens are causing disease. This knowledge in its turn opens up novel possibilities to combat infections by interfering with these mechanisms, a strategy that has been termed antivirulence therapy. In this review, the current knowledge with respect to pathogenicity mechanisms of bacterial aquaculture pathogens is discussed, including adhesion mechanisms, production of extracellular polysaccharides and biofilm formation, production of lytic enzymes (e.g. haemolysins and proteases), mechanisms of iron acquisition, secretion systems and regulatory mechanisms such as quorum sensing and host-pathogen signalling with catecholamine stress hormones. Furthermore, an overview is given of the first steps towards antivirulence therapy for aquaculture, with a focus on quorum sensing disruption as a proof of concept.
机译：尽管水产养殖仍然是全球增长最快的食品生产行业，但该部门在控制传染病方面面临着重要的挑战。的确，抗生素的频繁使用是传统上抵御细菌性疾病的最重要方法，它引起了与耐药性的发展和传播有关的问题。因此，我们目前正在开发新的疗法，该疗法应使我们将来能够继续控制细菌疾病。在这方面，过去几年的科学进步使我们开始了解细菌性病原体引起疾病的机制。反过来，这种知识为干扰感染开辟了新的可能性，这些机制被称为抗毒力疗法。在这篇综述中，讨论了有关细菌水产养殖病原体致病机制的当前知识，包括粘附机制，胞外多糖的产生和生物膜的形成，裂解酶（例如溶血素和蛋白酶）的产生，铁的获取，分泌系统和调节机制，例如群体感应和儿茶酚胺应激激素的宿主病原体信号传导。此外，概述了水产养殖抗病毒治疗的第一步，重点是群体感应破坏作为概念证明。

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