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首页> 外文期刊>Reviews in medical virology >Hepatitis B virus genotypes: comparison of genotyping methods.
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Hepatitis B virus genotypes: comparison of genotyping methods.

机译：乙肝病毒基因型：基因分型方法的比较。

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摘要

There are eight genotypes of HBV designated A to H based on greater than 8% nucleotide variation over the entire genome. Hepadnaviruses infecting primates like the chimpanzee, orangutan and gibbon are very similar and can be regarded as genotypes of HBV. The eight genotypes of HBV show a distinct geographical distribution and influence the course of disease and the prognosis of treatment. Due to the variability of HBV, diagnostic procedures risk giving false-negative results or reporting an inaccurately low quantitative result. Thus, the variability of HBV genotypes can influence the interpretation of diagnostic data and the therapeutic decisions thereof in an unwanted way. HBV genotypes differ in the length of their genomes. The old system of numbering HBV nucleotides from the start of a non-conserved EcoRI site in the genome leads to difficulties in comparing nucleotide positions between genotypes. A numbering system is presented which avoids this problem. In addition we discuss the currently available methods for genotyping HBV.
机译：基于整个基因组中大于8％的核苷酸变异，有八种HBV基因型被命名为A至H。感染灵长类动物（例如黑猩猩，猩猩和长臂猿）的肝炎病毒非常相似，可以视为HBV的基因型。 HBV的8个基因型显示出明显的地理分布，并影响疾病进程和治疗预后。由于HBV的变异性，诊断程序可能会给出假阴性结果或报告的定量结果不准确。因此，HBV基因型的变异性可能以不需要的方式影响诊断数据的解释及其治疗决策。 HBV基因型的基因组长度不同。从基因组中非保守的EcoRI位点开始为HBV核苷酸编号的旧系统导致比较基因型之间核苷酸位置的困难。提出了避免该问题的编号系统。此外，我们讨论了HBV基因分型的当前可用方法。

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