...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Resuscitation. >Comparison of 30 and the 100% inspired oxygen concentrations during early post-resuscitation period: a randomised controlled pilot study.
【24h】

Comparison of 30 and the 100% inspired oxygen concentrations during early post-resuscitation period: a randomised controlled pilot study.

机译：在复苏后早期，比较30％和100％吸入的氧气浓度：一项随机对照试验研究。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: High oxygen concentration in blood may be harmful in the reperfusion phase after cardiopulmonary resuscitation. We compared the effect of 30 and 100% inspired oxygen concentrations on blood oxygenation and the level of serum markers (NSE, S-100) of neuronal injury during the early post-resuscitation period in humans. METHODS: Patients resuscitated from witnessed out-of-hospital ventricular fibrillation were randomised after the return of spontaneous circulation (ROSC) to be ventilated either with 30% (group A) or 100% (group B) oxygen for 60 min. Main outcome measures were NSE and S-100 levels at 24 and 48 h after ROSC, the adequacy of oxygenation at 10 and 60 min after ROSC and, in group A, the need to raise FiO(2) to avoid hypoxaemia. Blood oxygen saturation <95% was the threshold for this intervention. RESULTS: Thirty-two patients were randomised and 28 (14 in group A and 14 in group B) remained eligible for the final analysis. The mean PaO(2) at 10 min was 21.1 kPa in group A and 49.7 kPa in group B. The corresponding values at 60 min were 14.6 and 46.5 kPa. PaO(2) values did not fall to the hypoxaemic level in group A. In another group FiO(2) had to be raised in five cases (36%) but in two cases it was returned to 0.30 rapidly. The mean NSE at 24 and 48 h was 10.9 and 14.2 microg/l in group A and 13.0 and 18.6 microg/l in group B (ns). S-100 at corresponding time points was 0.21 and 0.23 microg/l in group A and 0.73 and 0.49 microg/l in group B (ns). In the subgroup not treated with therapeutic hypothermia in hospital NSE at 24h was higher in group B (mean 7.6 versus 13.5 microg/l, p=0.0487). CONCLUSIONS: Most patients had acceptable arterial oxygenation when ventilated with 30% oxygen during the immediate post-resuscitation period. There was no indication that 30% oxygen with SpO(2) monitoring and oxygen backup to avoid SpO(2)<95% did worse that the group receiving 100% oxygen. The use of 100% oxygen was associated with increased level of NSE at 24h in patients not treated with therapeutic hypothermia. The clinical significance of this finding is unknown and an outcome-powered study is feasible.
机译：目的：在心肺复苏后的再灌注阶段，血液中高浓度的氧气可能有害。我们比较了在复苏后早期人类中30％和100％的吸入氧浓度对血液氧合以及神经元损伤的血清标志物（NSE，S-100）水平的影响。方法：自发性院外室性纤颤复苏的患者在自发循环（ROSC）恢复后随机分配，用30％（A组）或100％（B组）的氧气通气60分钟。主要结局指标包括ROSC后24和48小时的NSE和S-100水平，ROSC后10和60分钟的充氧程度，以及在A组中需要升高FiO（2）以避免低氧血症。血氧饱和度<95％是该干预的阈值。结果：32例患者被随机分组​​，其中28例（A组14例，B组14例）符合最终分析的条件。 A组在10分钟时的平均PaO（2）为21.1 kPa，B组为49.7kPa。60分钟时的相应值为14.6和46.5 kPa。 PaO（2）值未降至低氧血症水平（A组）。在另一组中，有5例（36％）的FiO（2）升高，但有2例迅速升高至0.30。 A组在24和48小时的平均NSE为10.9和14.2 microg / l，B组为13.0和18.6 microg / l（ns）。 A组在相应时间点的S-100分别为0.21和0.23 microg / l，B组则为0.73和0.49 microg / l（ns）。在医院，NSE 24小时未接受低温治疗的亚组中，B组较高（平均7.6对13.5 microg / l，p = 0.0487）。结论：大多数患者在复苏后即刻通入30％的氧气进行通气。没有迹象表明使用SpO（2）监测30％的氧气和备用氧气来避免SpO（2）<95％会使该组接受100％的氧气变得更糟。未经治疗性低温治疗的患者在24小时内使用100％氧气与NSE水平升高有关。该发现的临床意义尚不清楚，并且以结果为依据的研究是可行的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号