• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Physiology and Biochemistry >Lipid bilayers as osmotic response elements
【24h】

Lipid bilayers as osmotic response elements

机译：脂质双层作为渗透反应元件

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The importance of osmolarity in the regulation of a wide range of cellular functions and processes is well established. However, much less is known about the molecular mechanisms imparting sensitivity to osmotic forces to cells. The findings summarized in this brief review demonstrate that the principal structural element of all biomembranes, the lipid bilayer, provides a highly sensitive machinery for conveying information in the osmotic conditions of a cell to the relevant regulatory machineries. More specifically, osmotic shrinkage, swelling, as well as applied osmotic stress all have pronounced effects on the physical state and molecular interactions in the bilayer, influencing lipid packing and dynamics, and also altering the 2-dimensional (lateral) ordering in the membrane into compositionally distinct microdomains. Because of the cooperative behavior of lipid bilayers integrative regulation of the functions embedded in the different organelle membranes by the physical properties of lipids is possible. Organelle membranes should thus be understood as adaptive platforms harboring specialized metabolic pathways and functions, whose activities (physiological state) can be controlled by the physical state of the membrane lipids. Finally it is important to keep in mind that virtually all biological macromolecules maintain a hydration shell. Living cells thus constitute highly complex supramolecular assemblies, their numerous components responding to osmotic forces in unison. Copyright (C) 2000 S. Karger AG, Basel. [References: 47]
机译：渗透压在调节广泛的细胞功能和过程中的重要性已得到充分确立。然而，关于赋予细胞渗透力敏感性的分子机制知之甚少。在本简要综述中总结的发现表明，所有生物膜的主要结构要素，即脂质双层，提供了一种高度敏感的机制，可将细胞的渗透条件下的信息传递给相关的调节机制。更具体地说，渗透收缩，膨胀和施加的渗透压力均对双层中的物理状态和分子相互作用都有明显的影响，影响脂质堆积和动力学，并且还改变了膜中的二维（横向）排列。成分不同的微域。由于脂质双层的协同行为，通过脂质的物理性质对嵌入不同细胞器膜中的功能的整合调节是可能的。因此，应将细胞器膜理解为具有专门代谢途径和功能的适应性平台，其活动（生理状态）可以由膜脂的物理状态控制。最后，重要的是要记住，实际上所有生物大分子都具有水合壳。因此，活细胞构成了高度复杂的超分子组装体，它们的众多组成部分一致地对渗透力作出反应。版权所有（C）2000 S.Karger AG，巴塞尔。 [参考：47]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号