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首页> 外文期刊>Rheumatology >Salivary gland ultrasonography improves the diagnostic performance of the 2012 American college of rheumatology classification criteria for sj?gren's syndrome
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Salivary gland ultrasonography improves the diagnostic performance of the 2012 American college of rheumatology classification criteria for sj?gren's syndrome

机译：涎腺超声检查可提高2012年美国风湿病学院干燥综合征的诊断标准

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Objective: The aim of this study was to evaluate whether salivary gland ultrasonography (SGUS) improves the diagnostic performance of the 2012 ACR classification criteria for SS. Methods: We studied a cohort of 101 patients with suspected SS seen at a single centre in Brittany, France. An SGUS echostructure score ≥2 was considered abnormal. The reference standard was a clinical diagnosis of SS made by a group of experts blinded to SGUS findings. Results: SS was diagnosed in 45 patients. Similar proportions of patients with and without SS had an ocular staining score ≥3. Adding RF positivity and ANA titre 51:320 as an alternative to anti-SSA/SSB positivity increased the sensitivity of the serological item without modifying specificity compared with using anti-SSA/SSB alone. SGUS was 60.0% sensitive and 87.5% specific for SS. Adding the SGUS score to the ACR criteria increased sensitivity from 64.4% to 84.4% and only slightly decreased specificity, from 91.1% to 89.3%. Conclusion: The diagnostic performance of the ACR classification criteria for SS is notably improved by adding the SGUS score. SGUS should be included in future classification criteria for SS.
机译：目的：本研究的目的是评估唾液腺超声检查（SGUS）是否能改善2012年ACR分类标准对SS的诊断性能。方法：我们在法国布列塔尼的一个中心研究了101例疑似SS患者。 SGUS回声结构评分≥2被视为异常。参考标准是对SGUS结果不知情的一组专家对SS的临床诊断。结果：SS被诊断出45例。有和没有SS的患者的相似比例的眼部染色得分≥3。与单独使用抗SSA / SSB相比，增加RF阳性和ANA滴度51：320作为抗SSA / SSB阳性的替代方法可提高血清学项目的灵敏度，而不会改变特异性。 SGUS对SS的敏感性为60.0％，特异性为87.5％。将SGUS评分添加到ACR标准中可使敏感性从64.4％提高到84.4％，而特异性仅从91.1％降低到89.3％。结论：通过添加SGUS评分，ACR分类标准对SS的诊断性能得到明显改善。 SGUS应该包括在SS的未来分类标准中。

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