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首页> 外文期刊>Rheumatology >Increase in peripheral benzodiazepine receptors on monocytes in fibromyalgia.
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Increase in peripheral benzodiazepine receptors on monocytes in fibromyalgia.

机译：纤维肌痛单核细胞外周苯并二氮杂pine受体增加。

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OBJECTIVE: The aim of this study is to evaluate the expression of Peripheral Benzodiazepine Receptors (PBRs) on leukocytes in patients affected by primary fibromyalgia and to argue their possible role in pain perception and in modulation of immunologic process. METHODS: The expression of PBRs has been evaluated by flow cytometry on monocytes, on lymphocytes and on granulocytes in twenty patients with primary fibromyalgia, with indirect immunofluorescence methods. RESULTS: Upregulation of leukocyte PBRs expression has been demonstrated in fibromyalgia. A statistically significant difference has been documented only in monocytes. The monocyte PBRs expression was 26.74 +/- 14.84 MIF in fibromyalgia versus 17.45 +/- 8.54 MIF in controls (P < 0.023). Upregulation of PBRs expression, although not statistically significant, was also observed in lymphocytes and granulocytes. CONCLUSIONS: The monocyte PBRs overincrease in fibromyalgia may be due to abnormalities in the regulation of pain or to inflammation. It might perhaps explicate the possible mechanisms of therapeutic response to benzodiazepine in fibromyalgia.
机译：目的：本研究旨在评估原发性纤维肌痛患者外周血中苯二氮卓类受体（PBRs）在白细胞中的表达，并探讨其在疼痛感知和免疫过程调节中的可能作用。方法：采用间接免疫荧光法，通过流式细胞术评估了20例原发性纤维肌痛患者单核细胞，淋巴细胞和粒细胞中PBRs的表达。结果：在纤维肌痛中已证实白细胞PBRs表达上调。仅单核细胞有统计学上的显着差异。纤维肌痛中单核细胞PBRs表达为26.74 +/- 14.84 MIF，而对照组为17.45 +/- 8.54 MIF（P <0.023）。尽管在统计学上不显着，但在淋巴细胞和粒细胞中也观察到PBRs表达的上调。结论：纤维肌痛中单核细胞PBRs过度增加可能是由于疼痛调节异常或炎症所致。它可能阐明了纤维肌痛对苯二氮卓类药物治疗反应的可能机制。

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