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首页> 外文期刊>RSC Advances >Surface modified PMMA nanoparticles with tunable drug release and cellular uptake
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Surface modified PMMA nanoparticles with tunable drug release and cellular uptake

机译：具有可调节的药物释放和细胞吸收功能的表面改性PMMA纳米颗粒

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摘要

In this manuscript, we report the microemulsion mediated synthesis of fluorophore-doped PMMA nanoparticles, with different sizes and surface coatings, for potential biomedical applications. Size variation was achieved by modulating the amount of co-surfactant n-butanol. After synthesis, their size, surface, and optical properties were evaluated. Nanoencapsulation was found to enhance the stability of the fluorophore against chemically induced quenching. The surface of the nanoparticles was modulated via coating with hydrophilic polymers PAA and PVA. Hydrophilic coating resulted in enhancement of the colloidal stability of these nanoparticles in physiological saline medium. The release pattern of the encapsulated fluorophore was found to depend on both the size and surface properties of the nanoparticles. Fluorescence bioimaging and fluorescence analysis of lysates of treated cells were used to study the cellular uptake of the nanoparticles. The cellular uptake was also found to depend on both size and surface properties of these nanoparticles. Finally, cell viability (MTT) assay in vitro has indicated the absence of cytotoxic effects of these doped nanoparticles. These results underscore the promise of these nanoparticles in non-toxic biomedical applications.
机译：在此手稿中，我们报告了微乳液介导的荧光团掺杂的PMMA纳米颗粒的合成，具有不同的尺寸和表面涂层，可用于潜在的生物医学应用。通过调节助表面活性剂正丁醇的量来实现尺寸变化。合成后，评估它们的尺寸，表面和光学性质。发现纳米囊封增强了荧光团抵抗化学诱导的猝灭的稳定性。纳米颗粒的表面通过用亲水性聚合物PAA和PVA涂覆来调节。亲水涂层导致这些纳米颗粒在生理盐水培养基中的胶体稳定性增强。发现包封的荧光团的释放模式取决于纳米颗粒的尺寸和表面性质。使用荧光生物成像和处理细胞裂解物的荧光分析来研究纳米颗粒的细胞摄取。还发现细胞摄取取决于这些纳米颗粒的尺寸和表面性质。最后，体外细胞生存力（MTT）分析表明，这些掺杂的纳米颗粒没有细胞毒性作用。这些结果强调了这些纳米颗粒在无毒生物医学应用中的前景。

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