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首页> 外文期刊>RSC Advances >Mesoporous NaYF4:Yb,Er@Au-Pt(IV)-FA nanospheres for dual-modal imaging and synergistic photothermal/chemo-anti-cancer therapy
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Mesoporous NaYF4:Yb,Er@Au-Pt(IV)-FA nanospheres for dual-modal imaging and synergistic photothermal/chemo-anti-cancer therapy

机译：介孔NaYF4：Yb，Er @ Au-Pt（IV）-FA纳米球用于双模式成像和协同光热/化学抗癌治疗

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In this report, mesoporous NaYF4:Yb,Er@Au-Pt(IV)-FA up-conversion nanoparticles (UCNPs) have been designed by attaching Au NPs and Pt(IV) pro-drugs on the surface of PEI hydrogel modified mesoporous NaYF4:Yb, Er nanospheres. Finally the molecules modified with folic acid (FA) improve the receptor-mediated endocytosis. Because of the doped rare earth ions in the host matrix, the as-synthesized platform exhibits excellent up-conversion luminescence (UCL) imaging and computed X-ray tomography (CT) imaging properties. Diverse methods including MTT assay, hemolysis experiments, and live/dead cell analysis were employed to evaluate the biocompatibility and ablation efficacy of the as-synthesized platform. It was found that the cytotoxicity of the platform can be tuned by eliminating the axial ligands reductively during intracellular endocytosis. Especially, under 980 nm near-infrared (NIR) irradiation, the platform shows excellent inhibition toward cancer cells due to the synergistic photothermal injury to enzymes and membrane integrity combined with the DNA binding of activated Pt(II) to avoid cell proliferation. The developed nanocomposite may thus be a promising imaging-guided synergistic anti-cancer platform.
机译：在本报告中，通过在PEI水凝胶修饰的介孔NaYF4表面附着Au NP和Pt（IV）前药，设计了介孔NaYF4：Yb，Er @ Au-Pt（IV）-FA上转换纳米粒子（UCNP）。 ：Yb，Er纳米球。最后，用叶酸（FA）修饰的分子改善了受体介导的内吞作用。由于主体基质中掺杂了稀土离子，因此合成平台具有出色的上转换发光（UCL）成像和计算机X射线断层扫描（CT）成像性能。使用包括MTT分析，溶血实验和活细胞/死细胞分析在内的多种方法来评估合成平台的生物相容性和消融效果。已经发现，可以通过在细胞内吞过程中还原性地消除轴向配体来调节平台的细胞毒性。特别是，在980 nm近红外（NIR）辐射下，该平台由于对酶的协同光热损伤和膜完整性以及活化的Pt（II）的DNA结合，从而避免了细胞增殖，对癌细胞具有优异的抑制作用。因此，开发的纳米复合材料可能是一个有前途的成像指导的协同抗癌平台。

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