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首页> 外文期刊>Rheumatology >Nephrogenic systemic fibrosis is associated with hypophosphataemia: A case-control study
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Nephrogenic systemic fibrosis is associated with hypophosphataemia: A case-control study

机译：肾源性系统性纤维化与低血磷症相关：病例对照研究

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Objective: Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs). Derangements of calcium and phosphorus have been reported in patients with NSF. The aim of this study was to investigate potential factors in addition to GBCA exposure that may be involved in the pathogenesis of NSF. We hypothesized that patients with stage 5 CKD and NSF would manifest greater alterations in calcium, phosphorus and fibroblast growth factor 23 (FGF23) levels than those who do not have NSF. Methods: Levels of phosphorus, calcium, FGF23 and 25-hydroxy-vitamin D were measured in 10 patients with stage 5 CKD and biopsy-proven NSF and in 19 patients with stage 5 CKD without NSF. Statistical analyses were performed using Fisher's exact test for categorical variables and the Kruskal-Wallis test for continuous variables. Results: Patients with NSF had significantly lower phosphorus levels compared with controls (P = 0.01). There were no significant differences between NSF patients and controls in calcium, 25-hydroxy-vitamin D, intact parathyroid hormone or FGF23 levels. Conclusion: Differences in phosphorus metabolism may exist between patients with stage 5 CKD and NSF compared with patients with stage 5 CKD without NSF.
机译：目的：肾源性系统性纤维化（NSF）是一种医源性纤维化疾病，主要暴露于以g为基础的造影剂（GBCAs）后患有慢性肾脏疾病（CKD）的个体。 NSF患者中钙和磷的排列紊乱已有报道。这项研究的目的是调查除GBCA暴露外可能与NSF发病机制有关的潜在因素。我们假设患有5期CKD和NSF的患者会比没有NSF的患者表现出更大的钙，磷和成纤维细胞生长因子23（FGF23）水平变化。方法：对10例5期CKD并经活检证实的NSF患者和19例5期CKD而无NSF的患者进行了血磷，钙，FGF23和25-羟基维生素D的测定。使用分类精确变量的Fisher精确检验和连续变量的Kruskal-Wallis检验进行统计分析。结果：与对照组相比，NSF患者的磷水平显着降低（P = 0.01）。 NSF患者与对照组之间的钙，25-羟基维生素D，完整的甲状旁腺激素或FGF23水平无显着差异。结论：与没有NSF的5期CKD患者相比，患有5期CKD和NSF的患者之间可能存在磷代谢差异。

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