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首页> 外文期刊>RSC Advances >Poly(glycerol sebacate)-modified polylactic acid scaffolds with improved hydrophilicity, mechanical strength and bioactivity for bone tissue regeneration
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Poly(glycerol sebacate)-modified polylactic acid scaffolds with improved hydrophilicity, mechanical strength and bioactivity for bone tissue regeneration

机译：聚（癸二酸甘油酯）改性的聚乳酸支架，具有改善的亲水性，机械强度和生物活性，可促进骨组织再生

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摘要

Polylactic acid (PLA) has been extensively researched in biomedical engineering applications due to its superior mechanical strength and biocompatibility in vivo. But the inherent brittleness, slow degradability and inferior hydrophilicity greatly hamper its successful application. Here, a biodegradable crosslinked elastomer poly(glycerol sebacate) (PGS) was adapted to modify PLA scaffold for bone tissue engineering in this study. A highly interconnected and large porous, three-dimensional (3D) PLA-based scaffold was prepared by a NaCl particulate-leaching method and the PGS prepolymer (pre-PGS) was introduced either by pre-molding binary blend (B.B) or by surface coating (S.C) of a homogeneous PGS onto PLA-based scaffolds with and without oxygen plasma pretreatment (O.P and D.C). After curing at 130 degrees C, the resulting PLA/PGS scaffolds all exhibited well interconnected open-cell structures. The incorporation of PGS to PLA both by B.B and S.C could effectively improve the hydrophilicity, degradation, toughness and ductility, and the best efficacy was observed for the S.C with the oxygen plasma pretreatment. Specifically, at the ratio of PLA/PGS 9 : 1 and 7 : 3, the fracture strain of the PLA/PGS scaffolds by O.P were improved from 8% (pure PLA) to 13% and 24%, respectively. Further studies indicated that enhanced hydrophilicity and increased surface roughness were the main contributors to the above positive effect of oxygen-based plasma treatment. Additionally, these hybrid PLA/PGS scaffolds exhibited good mineralization, high cell biocompatibility, and enhanced cell adhesion and osteogenic differentiation for bone mesenchymal stem cells (BMSCs), especially for scaffolds by S.C. The present results suggest that the surface coating of PGS with oxygen-based plasma pretreatment is an effective strategy to modify the properties of PLA and the hybrid PLA/PGS scaffold represents a promising candidate in the formulation of bone tissue regeneration.
机译：聚乳酸（PLA）由于其优越的机械强度和体内生物相容性，已在生物医学工程应用中进行了广泛的研究。但是固有的脆性，缓慢的降解性和较差的亲水性极大地阻碍了其成功的应用。在此研究中，可生物降解的交联弹性体聚癸二酸甘油酯（PGS）用于修饰PLA支架以用于骨组织工程。通过NaCl微粒浸提法制备了高度互连且大型的多孔，三维（3D）PLA基支架，并通过预成型二元共混物（BB）或通过表面引入了PGS预聚物（pre-PGS）在有和没有氧等离子体预处理（OP和DC）的情况下，将均质PGS涂层（SC）涂覆到PLA支架上。在130℃下固化后，所得的PLA / PGS支架全部表现出良好的互连开孔结构。 B.B和S.C将PGS掺入PLA均能有效改善亲水性，降解，韧性和延展性，氧等离子体预处理对S.C的效果最佳。具体而言，以PLA / PGS 9：1和7：3的比例，通过O.P将PLA / PGS支架的断裂应变从8％（纯PLA）分别提高到13％和24％。进一步的研究表明，增强的亲水性和增加的表面粗糙度是上述基于氧的等离子体处理的积极作用的主要贡献者。此外，这些杂合的PLA / PGS支架对于骨骼间充质干细胞（BMSC），尤其是SC支架，表现出良好的矿化性，高细胞生物相容性以及增强的细胞粘附性和成骨分化。基于血浆的预处理是改变PLA性能的有效策略，而杂化PLA / PGS支架代表了骨组织再生配方中的有希望的候选者。

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