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首页> 外文期刊>RSC Advances >Multiwall carbon nanotube-modified electrode as a nanosensor for electrochemical studies and stripping voltammetric determination of an antimalarial drug
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Multiwall carbon nanotube-modified electrode as a nanosensor for electrochemical studies and stripping voltammetric determination of an antimalarial drug

机译：多壁碳纳米管修饰电极作为纳米传感器用于电化学研究和溶出伏安法测定抗疟药

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摘要

A sensitive electrochemical method based on adsorptive stripping differential pulse voltammetry (AdSDPV) developed for the determination of an antimalarial drug, hydroxychloroquine (HCQ), using a multi-walled carbon nanotube (MWCNTs)-modified carbon paste electrode (MWCNTs/CPE). The modified nanosensor due to its enhanced conductivity showed a very large current response from the electroactive substrate. The modified electrode was characterized by different methods such as scanning electron microscopy (SEM) and cyclic voltammetry (CV). Also, some techniques including CV, chronoamperometry (CHA) and chronocoulometry (CHC) were used for electrochemical studies of HCQ. It was observed that by employing MWCNTs/CPE, a 4-fold enhancement in the HCQ signal was observed as compared to the carbon paste electrode (MWCNTs/CPE). Under the optimized conditions, the differential pulse voltammetric peak current was proportional to the HCQ concentration in the range of 5.7 x 10(-8) M to 1 x 10(-4) M with a detection limit (S/N = 3) of 6.0 nM. The analytical applications of the modified sensor were demonstrated by estimating HCQ in pharmaceutical formulations and biological fluids. Also, the modified electrode showed good reproducibility, long-term stability and anti-fouling effects.
机译：一种基于吸附溶出差分脉冲伏安法（AdSDPV）的灵敏电化学方法，用于使用多壁碳纳米管（MWCNTs）修饰的碳糊电极（MWCNTs / CPE）测定抗疟药羟氯喹（HCQ）。改性的纳米传感器由于其增强的导电性而显示出来自电活性基材的非常大的电流响应。通过不同的方法，如扫描电子显微镜（SEM）和循环伏安法（CV），对改性电极进行了表征。同样，一些技术包括CV，计时电流法（CHA）和计时库仑法（CHC）被用于HCQ的电化学研究。观察到，通过使用MWCNT / CPE，与碳糊电极（MWCNT / CPE）相比，HCQ信号提高了4倍。在最佳条件下，差分脉冲伏安峰值电流与HCQ浓度成正比，范围为5.7 x 10（-8）M到1 x 10（-4）M，检测极限（S / N = 3）为6.0 nM。通过估计药物制剂和生物液中的HCQ证明了改进型传感器的分析应用。而且，改性电极显示出良好的再现性，长期稳定性和防污效果。

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