Physiology and pathophysiology of the RANKL/RANK system.

Hanada R; Hanada T; Penninger JM

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Physiology and pathophysiology of the RANKL/RANK system.

机译：RANKL / RANK系统的生理学和病理生理学。

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The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.

机译：TNF家族分子RANKL及其受体RANK是怀孕期间骨骼重塑，淋巴结形成和乳腺发育的关键调节剂。 RANKL和RANK也在中枢神经系统（CNS）中表达。但是，RANKL / RANK在大脑中的功能相关性是完全未知的。最近，我们的小组报告说，RANKL / RANK信号通路在通过前列腺素轴对体温的中央调节中起着至关重要的作用。这篇综述讨论了RANKL / RANK系统作为发烧和中枢神经系统女性基础体温的关键调节因素的新颖方面。

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《Biological chemistry》 |2010年第12期|共6页
作者
Hanada R; Hanada T; Penninger JM;
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正文语种 eng
中图分类生物化学;
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1. Physiology and pathophysiology of the RANKL/RANK system. [J] . Hanada R, Hanada T, Penninger JM Biological chemistry . 2010,第12期

机译：RANKL / RANK系统的生理学和病理生理学。
2. Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. [J] . Tanaka S, Nakamura K, Takahasi N, Immunological reviews. . 2005,第0期

机译：RANKL在生理和病理学骨吸收中的作用以及靶向RANKL-RANK信号系统的治疗剂。
3. Physiology and pathophysiology of the RANKL/RANK system [J] . Vanessa Nicolin, Stefania Lucia Nori, Renato Bareggi, Italian Journal of Anatomy and Embryology . 2011,第2期

机译：RANKL / RANK系统的生理学和病理生理学
4. Molecular docking of the active compound Garcinia mangostana on the RANKL/RANK/OPG system [C] . B Setiawan, E Suhartono, S Kaidah, International Seminar on Smart Molecule of Natural Resources . 2020

机译：在Rankl /等级/ OPG系统上的活性化合物Garcinia Mangostana的分子对接
5. Characterization of Medication Related Osteonecrosis of the Jaws Pathophysiology and Local RANKL Delivery as an Experimental Intervention [D] . Soundia, Akrivoula. 2020

机译：颌骨治疗的药物治疗骨折病理生理学和局部RANKL交付作为实验干预的特征
6. Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden [O] . Luis F de Castro, Andrea B Burke, Howard D Wang, -1

机译：RANK / RANKL / OPG途径的激活涉及纤维异常增生的病理生理学并与疾病负担相关
7. Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden [O] . Luis F de Castro, Andrea B Burke, Howard D Wang, 2018

机译：等级/ RANKL / OPG途径的激活涉及纤维发育不良的病理生理学，与疾病负担相关

Physiology and pathophysiology of the RANKL/RANK system.

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