...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Occupational and environmental medicine >Cross sectional and longitudinal study on selenium, glutathione peroxidase, smoking, and occupational exposure in coal miners.
【24h】

Cross sectional and longitudinal study on selenium, glutathione peroxidase, smoking, and occupational exposure in coal miners.

机译：煤矿工人硒，谷胱甘肽过氧化物酶，吸烟和职业暴露的横断面和纵向研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: To understand the variations of selenium (Se) concentration relative to changes in occupational exposure to coal dust, taking into account age and changes in smoking habits in miners surveyed twice, in 1990 and 1994. To better understand the relation of Se concentration with glutathione peroxidase activities (GSH-Px) in these miners. METHODS: In 1994, blood samples were obtained from active (n=131) and retired (n=40) miners without coal worker's pneumoconiosis, in whom Se concentration was available at both surveys and in whom International Labour Organisation (ILO) profusion grade had not been changed. Active miners were exposed to high dust concentrations (n=48) or low dust concentrations (n=83). Miners were classified into three subgroups according to their estimated cumulative exposure to dust, and into three subgroups according to their smoking habits. RESULTS: Selenium concentration and GSH-Px activities were significantly lower in active than in retired miners (Se adjusted means: 62.6 v 72.2 ng/ml p=0.01). Moreover, Se concentration was lower in miners exposed to high compared with those exposed to low dust concentrations (adjusted means: 59.4 v 65.8). In miners exposed to high dust concentrations, Se concentration was significantly lower whereas erythrocyte GSH-Px activity was significantly higher in the subgroup with estimated cumulative exposure >68 mg/m(3).y. In all miners, plasma GSH-Px activity was correlated with Se concentration (r=0.22, p<0.005). The 4 year Se changes were negatively related to exposure to high dust concentrations and positively related to change in exposure from high to retirement and to change from smoker to ex-smoker (p=0.01). CONCLUSION: The variations of Se concentration in relation to changes in occupational exposure to coal dust and in smoking habits, and the close correlation found between plasma Se concentration and GSH-Px activity suggest that both are required in antioxidant defence. These results agree well with the hypothesis that the decrease in Se concentration reflects its use against reactive oxygen species generated by exposure to coal mine dust and by smoking.
机译：目的：了解硒（Se）浓度相对于职业接触煤尘的变化的变化，并考虑到1990年和1994年两次调查的矿工的年龄和吸烟习惯的变化。更好地了解硒浓度与这些矿工中的谷胱甘肽过氧化物酶活性（GSH-Px）。方法：1994年，从没有煤矿工人尘肺病的活跃矿工（n = 131）和退休矿工（n = 40）的采血者中抽取了血样，两次调查均获得了硒浓度，并且国际劳工组织（ILO）的充血等级为没有改变。活跃的矿工暴露于高粉尘浓度（n = 48）或低粉尘浓度（n = 83）。矿工根据估计的粉尘累积暴露量分为三个亚组，根据吸烟习惯将其分为三个亚组。结果：活动中的硒浓度和GSH-Px活性显着低于退休矿工（硒调整后的平均值为：62.6 v 72.2 ng / ml p = 0.01）。此外，高尘矿工的硒含量比低尘矿工的硒含量低（调整后的平均值为：59.4 v 65.8）。在暴露于高粉尘浓度的矿工中，该亚组的硒浓度显着较低，而红细胞的GSH-Px活性显着较高，估计累积暴露量> 68 mg / m（3）.y。在所有矿工中，血浆GSH-Px活性与Se浓度相关（r = 0.22，p <0.005）。硒的4年变化与高浓度粉尘的暴露负相关，与从高浓度到退休的暴露以及从吸烟者到前吸烟者的变化呈正相关（p = 0.01）。结论：硒浓度的变化与职业接触煤尘和吸烟习惯的变化有关，并且血浆硒浓度与GSH-Px活性之间存在密切的相关性，这表明两者都需要抗氧化剂防御。这些结果与以下假设非常吻合：硒浓度的降低反映了其对暴露于煤矿粉尘和吸烟产生的活性氧物种的利用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号