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首页> 外文期刊>Occupational and environmental medicine >Exposure-response relations for self reported asthma and rhinitis in bakers.
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Exposure-response relations for self reported asthma and rhinitis in bakers.

机译：面包师自身报告的哮喘和鼻炎的暴露-反应关系。

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OBJECTIVES: To explore relations between two estimates of exposure to inhalable flour dust, and the incidence rates (IRs) of asthma and rhinitis in bakers. METHODS: This was a retrospective cohort study among 2923 bakers. A posted questionnaire registered the disease and work history. For every year, each baker was assigned an estimate of the exposure concentration to inhalable flour dust derived from reported job-tasks and dust measurements. Exposure at onset of disease was expressed as current dust exposure concentration, and as cumulative dose of exposure to dust. A multiple Poisson regression analysis assessed the impacts of the exposure estimates on the IRs of asthma and rhinitis. RESULTS: IRs of asthma and rhinitis increased by dust concentration at onset of disease. The IR of asthma for the bakers with highest exposure (dough makers) was 7. 3/1000 person-years in men and 6.5 in women and for rhinitis 43.4 and 38.5, respectively. There was a significant association between the dust concentration at onset of disease and the risk for asthma or rhinitis, but not of the cumulative exposure. CONCLUSION: The risk of asthma seemed to be increased at inhalable dust concentrations >/=3 mg/m(3) (dough making or bread forming), whereas the risk of rhinitis was increased at all concentrations >/=1 mg/m(3), indicating an increased risk in all bakery job-tasks. The risks seemed to be less dependent on the cumulative exposure dust than the inhalable dust concentrations.
机译：目的：探讨两种估计的可吸入粉尘暴露量与面包师哮喘和鼻炎的发生率之间的关系。方法：这是一项对2923名面包师进行的回顾性队列研究。张贴的调查表记录了疾病和工作经历。每年，每位面包师都会根据从报告的工作任务和粉尘测量中获得的可吸入面粉粉尘的暴露浓度估算值。疾病发作时的接触表示为当前的粉尘接触浓度，以及累积的粉尘接触剂量。多重Poisson回归分析评估了暴露估计值对哮喘和鼻炎IR的影响。结果：哮喘和鼻炎的IR在发病时因粉尘浓度增加而增加。暴露最高的面包师（面团制作者）的哮喘的IR分别为男性7. 3/1000人年，女性6.5人和鼻炎43.4和38.5。疾病发作时的粉尘浓度与哮喘或鼻炎的风险之间存在显着关联，但与累积暴露无关。结论：可吸入粉尘浓度> / = 3 mg / m（3）（面团或面包成型）时，哮喘风险似乎增加，而在所有浓度> / = 1 mg / m（）时，鼻炎风险增加3），表明所有面包店工作任务的风险均增加。与可吸入粉尘浓度相比，风险似乎对累积的暴露粉尘的依赖性较小。

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