...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Occupational and environmental medicine >Respiratory disease mortality among US coal miners; results after 37 years of follow-up
【24h】

Respiratory disease mortality among US coal miners; results after 37 years of follow-up

机译：美国煤矿工人的呼吸系统疾病死亡率;经过37年的随访

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: To evaluate respiratory related mortality among underground coal miners after 37 years of follow-up. Methods: Underlying cause of death for 9033 underground coal miners from 31 US mines enrolled between 1969 and 1971 was evaluated with life table analysis. Cox proportional hazards models were fi tted to evaluate the exposure-response relationships between cumulative exposure to coal mine dust and respirable silica and mortality from pneumoconiosis, chronic obstructive pulmonary disease (COPD) and lung cancer. Results: Excess mortality was observed for pneumoconiosis (SMR=79.70, 95% CI 72.1 to 87.67), COPD (SMR=1.11, 95% CI 0.99 to 1.24) and lung cancer (SMR=1.08; 95% CI 1.00 to 1.18). Coal mine dust exposure increased risk for mortality from pneumoconiosis and COPD. Mortality from COPD was significantly elevated among ever smokers and former smokers (HR=1.84, 95% CI 1.05 to 3.22; HRK=1.52, 95% CI 0.98 to 2.34, respectively) but not current smokers (HR=0.99, 95% CI 0.76 to 1.28). Respirable silica was positively associated with mortality from pneumoconiosis (HR=1.33, 95% CI 0.94 to 1.33) and COPD (HR=1.04, 95% CI 0.96 to 1.52) in models controlling for coal mine dust. We saw a significant relationship between coal mine dust exposure and lung cancer mortality (HR=1.70; 95% CI 1.02 to 2.83) but not with respirable silica (HR=1.05; 95% CI 0.90 to 1.23). In the most recent follow-up period (2000-2007) both exposures were positively associated with lung cancer mortality, coal mine dust signi ficantly so. Conclusions: Our findings support previous studies showing that exposure to coal mine dust and respirable silica leads to increased mortality from malignant and non-malignant respiratory diseases even in the absence of smoking.
机译：目的：评估37年随访后地下煤矿工人的呼吸系统相关死亡率。方法：通过生命表分析评估了1969年至1971年间登记的31个美国煤矿的9033名地下煤矿工人的潜在死亡原因。筛选Cox比例风险模型以评估煤矿尘埃和可吸入二氧化硅的累积暴露与尘肺，慢性阻塞性肺病（COPD）和肺癌的死亡率之间的暴露-反应关系。结果：尘肺病（SMR = 79.70，95％CI 72.1至87.67），COPD（SMR = 1.11，95％CI 0.99至1.24）和肺癌（SMR = 1.08; 95％CI 1.00至1.18）观察到过高的死亡率。煤矿粉尘暴露会增加尘肺和COPD致死的风险。以往吸烟者和以前吸烟者的COPD死亡率均显着升高（HR分别为1.84，95％CI 1.05至3.22; HRK = 1.52，95％CI 0.98至2.34），而目前吸烟者则没有（HR = 0.99，95％CI 0.76至1.28）。在控制煤矿粉尘的模型中，可吸入二氧化硅与尘肺病（HR = 1.33，95％CI 0.94至1.33）和COPD（HR = 1.04，95％CI 0.96至1.52）的死亡率呈正相关。我们发现煤矿粉尘暴露与肺癌死亡率之间存在显着相关性（HR = 1.70; 95％CI 1.02至2.83），而与可吸入二氧化硅无关（HR = 1.05; 95％CI 0.90至1.23）。在最近的随访期（2000-2007年）中，两次接触均与肺癌死亡率呈正相关，而煤矿粉尘显着相关。结论：我们的发现支持以前的研究，这些研究表明，即使没有吸烟，暴露于煤矿粉尘和可吸入二氧化硅也会导致恶性和非恶性呼吸道疾病的死亡率增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号