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首页> 外文期刊>Revue de Medecine Veterinaire >Protective effects of caffeic acid phenethyl ester, ellagic acid, sulforaphan and curcuma on malathion induced damage in lungs, liver and kidneys in an acute toxicity rat model
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Protective effects of caffeic acid phenethyl ester, ellagic acid, sulforaphan and curcuma on malathion induced damage in lungs, liver and kidneys in an acute toxicity rat model

机译：咖啡酸苯乙酯，鞣花酸，萝卜硫素和姜黄素对急性毒性大鼠模型中马拉硫磷诱导的肺，肝和肾损伤的保护作用

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The aim of this study was to investigate the possible protective effects of caffeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphan (SFN) and curcuma (CUR) against acute malathion (MAL) poisoning in rats. For that, 60 female adult Sprague-Dawley rats were randomly divided into 10 equal groups according to the treatment: whereas one group served as unmedicated control and another was intoxicated with malathion (200 mg/kg, per os) and served as positive control, rats from the other groups were treated with each of the four antioxidants (CAPE: 10 umol/kg, intraperitoneally, EA: 85 mg/kg, per os, SFN: 0.5 mg/kg, per os and CUR: 1 g/kg, per os) alone or in combination with malathion. One day, later, serum AChE (acetylcholinesterase), amylaseand GGT (gamma-glutamyltransferase) activities were determined and a histopathological evaluation was performed on lungs, kidneys and liver. In MAL-intoxicated rats, the AChE activity was markedly depleted whereas the GGT and amylase activities were significantiy increased compared to the unmedicated controls. In parallel, severe and extended inflammatory and degenerative cell lesions were evidenced in liver, kidneys and lungs. By contrast, changes in the serum enzyme activities were greatly attenuatedand the organ damage was also markedly reduced but not completely abrogated when an antioxidant cotreatment has been instituted. In addition, CUR appeared as the more efficient for hindering biochemical and histopathological alterations induced by malathion. These results show the protective effects of CAPE, EA, SFN and CUR on acute malathion poisoning in rats.
机译：这项研究的目的是研究咖啡酸苯乙酯（CAPE），鞣花酸（EA），萝卜硫素（SFN）和姜黄素（CUR）对大鼠急性马拉硫磷（MAL）中毒的可能保护作用。为此，根据治疗方法，将60只成年雌性Sprague-Dawley大鼠随机分为10组，每组分别作为非药物对照组和马拉硫磷中毒（口服200 mg / kg）作为阳性对照，用其他四种抗氧化剂分别对其他组的大鼠进行治疗（CAPE：10 umol / kg，腹膜内，EA：85 mg / kg，口服，SFN：0.5 mg / kg，口服，CUR：1 g / kg，每操作系统）单独或与马拉硫磷联用。一天后，测定血清AChE（乙酰胆碱酯酶），淀粉酶和GGT（γ-谷氨酰转移酶）的活性，并对肺，肾和肝进行组织病理学评估。与未用药的对照组相比，在MAL中毒的大鼠中，AChE活性显着减少，而GGT和淀粉酶活性显着增加。同时，在肝，肾和肺中证实了严重和延长的炎性和变性细胞病变。相反，当建立抗氧化剂共同治疗后，血清酶活性的变化大大减弱，器官损伤也明显减少，但并未完全消除。此外，CUR似乎在阻止马拉硫磷引起的生化和组织病理学改变方面更为有效。这些结果表明CAPE，EA，SFN和CUR对大鼠急性马拉硫磷中毒的保护作用。

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