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首页> 外文期刊>Reproductive toxicology >Effects of lactational administration of acrylamide on rat dams and offspring.
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Effects of lactational administration of acrylamide on rat dams and offspring.

机译：哺乳期施用丙烯酰胺对大鼠大坝和后代的影响。

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摘要

We duplicated the study design of Husain et al. (Ind Health 1987; 25:19-28) to determine whether maternal exposure to acrylamide monomer (AM) resulted in offspring neurotoxicity. Wistar rat dams with litters (15/group) were gavaged with AM in saline at 0 or 25.0 mg/kg/d throughout lactation (pnd 0-21). Maternal feed and water consumption, body weights (BW), and Functional Observational Battery (FOB) were recorded. At weaning (pnd 21), maternal sciatic nerves were examined histologically. Male offspring were retained until pnd 91, with BW and grip strength evaluations. Dosed dams exhibited progressive toxicity, including mortality (two), severely reduced feed and water consumption, BW, and BW gain, and behavioral neurotoxicity (with no sciatic nerve pathology). Nursing offspring at 25.0 mg/kg/d exhibited increased mortality and reduced BW associated with littleo milk in stomachs. Postwean males at 25.0 mg/kg/d exhibited normal BW gain and increasing grip strength over time. Therefore, AM caused maternal toxicity; offspring effects during lactation were consistent with inanition from maternal toxicity. Postwean males exhibited recovery with no signs of AM-mediated toxicity. These results do not support the conclusions of Husain et al.
机译：我们复制了侯赛因等人的研究设计。 （Ind Health 1987; 25：19-28）来确定母亲暴露于丙烯酰胺单体（AM）是否会导致后代神经毒性。在整个泌乳期间，以0或25.0 mg / kg / d的浓度在盐水中以AM喂食带有垫料的Wistar大鼠大坝（每组15只）（第0-21页）。记录母体饲料和水的消耗，体重（BW）和功能性观察电池（FOB）。在断奶时（第21页），通过组织学检查母亲坐骨神经。保留雄性后代直至第91胎，评估其体重和握力。计量水坝表现出进行性毒性，包括死亡率（两次），严重减少饲料和水的消耗，体重和体重增加以及行为神经毒性（无坐骨神经病理）。以25.0 mg / kg / d的剂量喂养后代会增加死亡率，并且由于很少/没有牛奶会降低BW。 25.0 mg / kg / d的断奶后男性表现出正常的体重增加，并且随着时间的推移握力增加。因此，AM引起产妇毒性。哺乳期的后代影响与母体毒性引起的影响一致。断奶后的男性表现出恢复，没有AM介导的毒性的迹象。这些结果不支持侯赛因等人的结论。

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