• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproductive toxicology >Phenanthrenequinone disrupts progesterone production in rat luteal cells.
【24h】

Phenanthrenequinone disrupts progesterone production in rat luteal cells.

机译：菲醌干扰大鼠黄体细胞中孕酮的产生。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The ability of the environmental contaminant phenanthrene (PH) and its photooxidized product phenanthrenequinone (PHQ) to disrupt progesterone secretion was examined in a model system of in vitro suspensions of luteal cells from the rat. Treatment with PHQ dramatically inhibited luteinizing hormone (LH) stimulated progesterone secretion. PHQ also generated a significant increase in reactive oxygen species (ROS). In the absence of LH, however, PHQ stimulated a small increase in basal progesterone secretion. The parent compound, PH, did not alter progesterone or ROS release. Since there is evidence that PHQ lowers the activity of nitric oxide synthase (NOS) and that nitric oxide (NO) affects progesterone production, we examined the response to the NOS inhibitors N-monomethyl-L-arginine, Zn protoporphyrin-9, and aminoguanidine in luteal cells. However, there was no effect of these agents on LH stimulated progesterone secretion. These results indicated that PHQ is a potent disrupter of progesterone secretion and should perhaps be considered in assessing the risk of PH to humans.
机译：在来自大鼠的黄体细胞体外悬浮液的模型系统中，检查了环境污染物菲（PH）及其光氧化产物菲醌（PHQ）破坏孕酮分泌的能力。用PHQ治疗可显着抑制促黄体激素（LH）刺激的孕激素分泌。 PHQ还显着增加了活性氧（ROS）。然而，在没有LH的情况下，PHQ刺激了基础孕激素分泌的少量增加。母体化合物PH不会改变孕酮或ROS的释放。由于有证据表明PHQ会降低一氧化氮合酶（NOS）的活性，并且一氧化氮（NO）影响孕酮的产生，因此我们研究了对NOS抑制剂N-单甲基-L-精氨酸，Zn原卟啉9和氨基胍的反应。在黄体细胞中。但是，这些药物对LH刺激的孕激素分泌没有作用。这些结果表明，PHQ是孕激素分泌的强力破坏者，在评估人类PH的风险时也许应该考虑使用PHQ。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号