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首页> 外文期刊>Reproductive toxicology >Effect of endosulfan on ovarian compensatory hypertrophy in hemicastrated albino mice.
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Effect of endosulfan on ovarian compensatory hypertrophy in hemicastrated albino mice.

机译：硫丹对白化的白化病小鼠卵巢代偿性肥大的影响。

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Endosulfan, a chlorinated cyclodiene insecticide, was administered orally at 1.5, 3, 6, and 9mg/kg per day to normal hemicastrated virgin mice for 15 consecutive days to examine the effect on ovarian function. Sham-operated and hemicastrated control mice were administered a similar volume of olive oil. The vaginal smear and body weight of the mice were recorded daily and mice were sacrificed on day 16. The remaining left ovary, uterus, kidney, adrenal, liver, thymus, and thyroid were removed and weighed. The left ovary from each animal was serially sectioned and stained for histologic studies. The hemicastrated control mice had a 40.5% increase in weight of the remaining left ovary and a significant increase in healthy and atretic follicles when compared with sham-operated controls. The remaining left ovaries of mice treated with 1.5mg endosulfan had a 37.2% increase in weight with no significant difference in ovarian weight and or in the healthy and atretic follicles when compared with hemicastrated olive oil-treated controls. However, treatment with 3, 6, and 9mg endosulfan resulted in weight increases in the remaining left ovary of only 14.9, 7.4, and 0.8% and a significant decrease in healthy follicles with a concomitant increase in the number of atretic follicles compared to the olive oil-treated controls. There was no significant change in the number of estrous cycles or the duration of each phase of the estrous cycle with 1.5 and 3mg/kg per day endosulfan. However, there was a significant decrease in the number of estrous cycles, and the duration of estrus and metestrus with a concomitant significant increase in the duration of the diestrus phase with 6 and 9mg/kg per day endosulfan treatment when compared with hemicastrated olive oil-treated controls. There were no significant change in body weight or the weights of the uterus, kidney, adrenal, liver, thymus, or thyroid after endosulfan treatment. These observations show that endosulfan treatment caused a significant decrease in compensatory ovarian hypertrophy. An increase in the number of atretic follicles and disruption of the estrous cycle may have been due to a direct effect on the ovary or to effects on the hypothalamo-hypophysial-ovarian axis.
机译：连续15天每天以1.5、3、6和9mg / kg的剂量口服硫丹（一种氯化的环二烯杀虫剂）给正常的半mic割的处女小鼠，以检查其对卵巢功能的影响。假手术和半鼻塞的对照小鼠被给予相似体积的橄榄油。每天记录小鼠的阴道涂片和体重，并在第16天处死小鼠。将剩余的左卵巢，子宫，肾脏，肾上腺，肝脏，胸腺和甲状腺取出并称重。将每只动物的左卵巢连续切片并染色以进行组织学研究。与假手术的对照组相比，经半结肠切除的对照组小鼠的剩余左卵巢重量增加了40.5％，健康卵泡和闭锁卵泡明显增加。与经半乳化橄榄油处理的对照组相比，用1.5mg硫丹处理的小鼠的其余左卵巢重量增加了37.2％，卵巢重量和/或健康和闭锁卵泡没有明显差异。但是，用3、6和9mg硫丹进行处理后，剩下的左卵巢重量仅增加了14.9、7.4和0.8％，健康卵泡显着减少，与橄榄相比，闭锁卵泡的数量也增加了经过油处理的对照。发情周期数或发情周期各阶段的持续时间均无明显变化，每天硫丹为1.5和3mg / kg。但是，与半乳化橄榄油相比，每天进行6和9mg / kg硫丹处理的发情期和发情期的持续时间显着减少，同时发情期的持续时间也显着增加，每日硫丹剂量分别为6mg / kg和-处理过的控件。硫丹治疗后，体重或子宫，肾脏，肾上腺，肝脏，胸腺或甲状腺的重量无明显变化。这些观察结果表明，硫丹治疗可导致代偿性卵巢肥大的明显减少。闭锁卵泡数目的增加和发情周期的破坏可能是由于对卵巢的直接影响或对下丘脑-垂体-卵巢轴的影响。

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