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首页> 外文期刊>Reproductive toxicology >Selective serotonin reuptake inhibitors (SSRIs) and heart defects: potential mechanisms for the observed associations.
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Selective serotonin reuptake inhibitors (SSRIs) and heart defects: potential mechanisms for the observed associations.

机译：选择性5-羟色胺再摄取抑制剂（SSRI）和心脏缺陷：观察到的协会的潜在机制。

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Several epidemiological investigations have shown an association between congenital heart defects and the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. At first glance this association may not seem to make biological sense, especially since, in many cases, serotonin is thought of as a neurotransmitter involved in signaling between neurons. However, serotonin also acts as a signaling molecule during embryogenesis affecting cell proliferation, migration, death, and differentiation. Serotonin may be particularly important for heart development and evidence suggests that from the time that progenitor heart cells are patterned during the establishment of laterality, to formation of the outflow tract, to myocardial cell differentiation, to septation of the heart chambers, the neurotransmitter may act as an important signaling molecule. Thus, numerous investigations have identified potential target sites where serotonin could regulate key cellular processes in cardiac development, thereby providing biological plausibility for the origin of heart defects caused by SSRIs.
机译：几项流行病学调查显示，先天性心脏缺陷与选择性5-羟色胺再摄取抑制剂（SSRI）类抗抑郁药之间存在关联。乍一看，这种联系似乎没有生物学意义，特别是因为在许多情况下，血清素被认为是参与神经元之间信号传递的神经递质。然而，血清素在胚胎发生过程中也起信号分子的作用，影响细胞的增殖，迁移，死亡和分化。 5-羟色胺对于心脏发育可能特别重要，证据表明，从侧向建立过程中祖细胞形成模式到流出通道的形成，心肌细胞的分化，心室的分隔，神经递质可能会发挥作用。作为重要的信号分子。因此，大量研究已经确定了5-羟色胺可以调节心脏发育中关键细胞过程的潜在靶位点，从而为SSRI引起的心脏缺陷的起源提供了生物学上的可行性。

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