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首页> 外文期刊>Reproductive toxicology >Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland.
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Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland.

机译：母体暴露于邻苯二甲酸二异壬基酯（DINP）和1,1-二氯-2,2-双（对氯苯基）乙烯（p，p'-DDE）对胎儿大鼠睾丸和肾上腺类固醇生成的影响。

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摘要

Exposure to antiandrogens during the critical developmental window (i.e. sexual differentiation) can permanently demasculinize the male phenotype. Here we have investigated the effects of developmental exposure to di-isononylphthalate (DINP) (250 and 750 mg/kg) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) (50 and 100mg/kg) on 19.5-day-old fetal Sprague-Dawley rat testicular and adrenal steroidogenesis. Maternal exposure to DINP or p,p'-DDE on embryonic days (EDs) 13.5-17.5 did not down-regulate the activity of steroidogenesis in ED 19.5 male rat fetus. Protein expression levels of testicular and adrenal StAR, P450scc, 3beta-HSD and androgen receptor (AR) did not show any changes. However, p,p'-DDE caused clear abnormalities in the ultrastructure of steroidogenic cells in ED 19.5 rat testis and adrenal. These structural alterations can disturb the development and function of fetal testis and adrenal that may become evident later in life.
机译：在关键的发育窗口（即性别分化）期间接触抗雄激素可永久消除男性表型的男性化。在这里，我们研究了发育暴露于邻苯二甲酸二异壬基酯（DINP）（250和750 mg / kg）和1,1-二氯-2,2-双（对氯苯基）乙烯（p，p'-DDE）的影响（50和100mg / kg）对19.5天大的胎儿Sprague-Dawley大鼠睾丸和肾上腺类固醇生成。母体在胚胎天（ED）13.5-17.5接触DINP或p，p'-DDE并没有下调ED 19.5雄性大鼠胎儿类固醇生成的活性。睾丸和肾上腺StAR，P450scc，3beta-HSD和雄激素受体（AR）的蛋白质表达水平未显示任何变化。然而，p，p'-DDE引起ED 19.5大鼠睾丸和肾上腺中类固醇生成细胞的超微结构明显异常。这些结构改变会干扰胎儿睾丸和肾上腺的发育和功能，这些可能在以后的生活中变得明显。

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