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首页> 外文期刊>Reproductive toxicology >The effect of prenatal and postnatal exposure to polychlorinated biphenyls and child neurodevelopment at age twenty four months
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The effect of prenatal and postnatal exposure to polychlorinated biphenyls and child neurodevelopment at age twenty four months

机译：产前和产后暴露于多氯联苯的影响以及二十四个月大的儿童神经发育的影响

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We examined the association between prenatal and postnatal exposure to PCBs and development at age 24 months as measured by the Bayley Scales of Infant Development II. 44 (85%) of 52 children had information available. When prenatal and postnatal exposure were modeled together, we found no association between total PCB exposure and the mental development index (MDI) or the physical development index (PDI). In examining PCB 153, we found no association between PCB 153 and MDI, while higher levels of postnatal exposure was associated with a decrease in PDI after adjustment [β for highest tertile = -24.9; 95% CI (-44.3, -5.5)]. Higher levels of prenatal PCB 153 exposure were associated with a statistically significant increased odds of screening positive for a motor delay. In sum, when prenatal and postnatal exposures were considered together, breast milk exposure to PCB 153 appears to be associated with decrements in motor development; however, we cannot rule out that the finding was due to chance.
机译：我们通过贝利婴儿发育量表II评估了出生前和产后PCBs暴露与24个月大时发育之间的关联。 52名儿童中有44名（85％）有可用信息。当对产前和产后暴露进行一起建模时，我们发现总PCB暴露与心理发育指数（MDI）或身体发育指数（PDI）之间没有关联。在检查PCB 153时，我们发现PCB 153与MDI之间没有关联，而调整后的出生后暴露水平较高与PDI降低相关[β最高三分位数= -24.9; 95％CI（-44.3，-5.5）]。较高水平的产前PCB 153暴露与运动延迟筛查阳性筛查的机率在统计学上显着相关。总之，将产前和产后暴露一起考虑时，母乳中多氯联苯153的暴露似乎与运动发育的下降有关。但是，我们不能排除该发现是偶然的。

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