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Annexins - Modulators of EGF receptor signalling and trafficking

机译：Annexins-EGF受体信号传导和运输的调节剂

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At the cell surface, activation of the epidermal growth factor (EGF) receptor triggers a complex network of signalling events that regulate a variety of cellular processes. For signal termination, the activated EGF receptor is internalised and targeted to lysosomes for degradation. Microdomain localization at the plasma membrane and endocytic transport of the EGFR is important for the formation of compartment-specific signalling complexes and is regulated by scaffolding and targeting proteins. This includes Ca2+-effector proteins, such as calmodulin and annexins (Anx), in particular AnxA1, AnxA2, AnxA6 and as shown recently, AnxA8. Given that these annexins show differences in their expression patterns, subcellular localization and mode of action, they are likely to differentially contribute and cooperate in the fine-tuning of EGFR activity. In support of this hypothesis, current literature suggests these annexins to be involved in different steps that control the endocytic transport and signalling of the EGF receptor. This review summarizes how the coordinated activity of AnxA1, AnxA2, AnxA6 and AnxA8 can contribute to regulate EGF receptor localization and activity.
机译：在细胞表面，表皮生长因子（EGF）受体的激活触发了调节各种细胞过程的复杂信号传递网络。对于信号终止，激活的EGF受体被内在化并靶向溶酶体进行降解。微结构域在质膜上的定位和EGFR的内吞转运对于形成区室特异性信号复合物很重要，并受支架和靶向蛋白的调节。这包括Ca 2+效应蛋白，例如钙调蛋白和膜联蛋白（Anx），特别是AnxA1，AnxA2，AnxA6，以及最近显示的AnxA8。鉴于这些膜联蛋白在其表达模式，亚细胞定位和作用方式上均表现出差异，因此它们可能在EGFR活性的微调中做出不同的贡献和协同作用。为了支持该假设，当前文献建议这些膜联蛋白参与控制EGF受体的内吞转运和信号传导的不同步骤。这篇综述总结了AnxA1，AnxA2，AnxA6和AnxA8的协调活性如何有助于调节EGF受体的定位和活性。

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