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首页> 外文期刊>Cellular Signalling >Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity

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Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity

机译：衔接子蛋白Nck1与p120 Ras GTPase激活蛋白相互作用并调节其活性

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摘要

Adaptor protein Nck1 binds a number of intracellular proteins and influences various signaling pathways. Here we show that Nck1 directly binds and activates the GTPase-activating protein of Ras (RasGAP), which is responsible for the down-regulation of Ras. The first and the third SH3 domains of Nck1 and the NH_2-terminal proline-rich sequence of RasGAP contribute most to the complex formation causing direct molecular interaction between the two proteins. Cell adhesion to the substrate is obligatory for the Nck1 and RasGAP association, as cell detachment makes RasGAP incapable of associating with Nck1. This leads to the complex dissipation, decrease of RasGAP activity and the increase of H-Ras-GTP level in the detached cells. Our findings reveal unexpected feature of adaptor protein Nck1 as the regulator of RasGAP activity.

机译：衔接蛋白Nck1结合许多细胞内蛋白并影响各种信号通路。在这里，我们显示Nck1直接结合并激活Ras的GTPase激活蛋白（RasGAP），后者负责Ras的下调。 Nck1的第一个和第三个SH3结构域以及RasGAP的富含NH_2末端的脯氨酸序列对复合物的形成贡献最大，从而导致两种蛋白质之间的直接分子相互作用。 Nck1和RasGAP的结合必须与细胞粘附，因为细胞分离使RasGAP无法与Nck1结合。这导致分离细胞中的复杂耗散，RasGAP活性降低和H-Ras-GTP水平升高。我们的发现揭示了衔接蛋白Nck1作为RasGAP活性调节剂的出乎意料的特征。

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《Cellular Signalling》 |2011年第10期|共8页
作者
Ger M.; Zitkus Z.; Valius M.;
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正文语种 eng
中图分类细胞形态学;
关键词
Adaptor proteins; Cell adhesion; Nck1; PDGF receptor; Ras GTPase; RasGAP;

机译：衔接蛋白;细胞粘附;Nck1;PDGF受体;Ras GTPase;RasGAP;

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专利

1. Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity [J] . Ger M., Zitkus Z., Valius M. Cellular Signalling . 2011,第10期

机译：衔接子蛋白Nck1与p120 Ras GTPase激活蛋白相互作用并调节其活性
2. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia [J] . Lubeck Beth A., Lapinski Philip E., Oliver Jennifer A., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2015,第1期

机译：前沿：T细胞中Ras GTP酶激活蛋白（RasGAP）Neurofibromin 1和p120 RasGAP的编码导致T细胞急性淋巴细胞白血病的发展
3. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia [J] . Beth A. Lubeck, Philip E. Lapinski, Jennifer A. Oliver, The journal of immunology . 2015,第1期

机译：前沿：T细胞中Ras GTP酶激活蛋白（RasGAP）Neurofibromin 1和p120 RasGAP的编码导致T细胞急性淋巴细胞白血病的发展
4. 14-3-3γinteracts with eIF1AX and RPS7 to regulate milk protein translation and cell proliferation in bovine mammary epithelial cells [C] . C.P.Yu, C.M.Wang, Q.Z.Li, 4th international symposium on dairy cow nutrition and milk quality proceedings . 2015

机译：14-3-3γ与eIF1AX和RPS7相互作用以调节牛乳腺上皮细胞中的乳蛋白翻译和细胞增殖
5. Cdc42-interacting protein family adaptors regulate endocytosis, membrane trafficking, migration, and invasion in cancer cells. [D] . Hu, Jinghui. 2011

机译：与Cdc42相互作用的蛋白家族适配器调节癌细胞的内吞作用，膜运输，迁移和侵袭。
6. Co-deletion of the Ras GTPase-activating proteins Neurofibromin 1 (NF1) and p120 RasGAP (RASA1) in T cells results in the development of T cell acute lymphoblastic leukemia [O] . Beth A. Lubeck, Philip E. Lapinski, Jennifer A. Oliver, -1

机译：在T细胞中共同缺失Ras GTP酶激活蛋白Neurofibromin 1（NF1）和p120 RasGAP（RASA1）导致T细胞急性淋巴细胞白血病的发展
7. p120 Ras GTPase-activating Protein Interacts with Ras-GTP through Specific Conserved Residues [O] . Wenyan Miao, Lori Eichelberger, Leroy Baker, 1996

机译：P120 RAS GTPase-Activating蛋白通过特定保守的残留物与RAS-GTP相互作用

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