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Computational identification of miRNA genes and their targets in

机译：miRNA基因及其靶标的计算鉴定

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MicroRNAs (miRNA) are a class of tiny non protein coding and regulatory RNA molecules about 18 to 26 nt in length. miRNA regulate gene expression via the degradation or translational inhibition of their target mRNAs. Nucleotide sequences of miRNAs are highly conserved among various organisms; this forms the key feature behind the identification of miRNAs in plant species by homology alignment. So far, little is known about miRNA in mulberry (Morus alba L.) species. In our study, a computational method was used for detection of mulberry miRNAs. A total of six miRNAs were identified. The six miRNAs may regulate twenty-two potential targets, which are predicted to encode transcription factors that regulate plant development, signaling, and metabolism. To validate the prediction of miRNAs in mulberry, a RT-PCR experimental method was performed and five of these miRNAs were found to be expressed
机译：微小RNA（miRNA）是一类微小的非蛋白质编码和调控RNA分子，长度约为18至26 nt。 miRNA通过降解或翻译抑制其靶mRNA来调节基因表达。 miRNA的核苷酸序列在各种生物中高度保守。这形成了通过同源比对鉴定植物物种中的miRNA背后的关键特征。到目前为止，关于桑树（Morus alba L.）物种中的miRNA知之甚少。在我们的研究中，一种计算方法被用于检测桑树miRNA。总共鉴定出六个miRNA。六个miRNA可能调控22个潜在的靶标，据预测它们可编码调控植物发育，信号传导和代谢的转录因子。为了验证桑树中miRNA的预测，进行了RT-PCR实验方法，发现其中有五个miRNA被表达

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