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首页> 外文期刊>Cellular & molecular biology letters. >Cannabinoid-like anti-inflammatory compounds from flax fiber
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Cannabinoid-like anti-inflammatory compounds from flax fiber

机译：亚麻纤维类大麻素类抗炎化合物

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摘要

Flax is a valuable source of fibers, linseed and oil. The compounds of the latter two products have already been widely examined and have been proven to possess many health-beneficial properties. In the course of analysis of fibers extract from previously generated transgenic plants overproducing phenylpropanoids a new terpenoid compound was discovered. The UV spectra and the retention time in UPLC analysis of this new compound reveal similarity to a cannabinoid-like compound, probably cannabidiol (CBD). This was confirmed by finding two ions at m/z 174. 1 and 231. 2 in mass spectra analysis. Further confirmation of the nature of the compound was based on a biological activity assay. It was found that the compound affects the expression of genes involved in inflammatory processes in mouse and human fibroblasts and likely the CBD from Cannabis sativa activates the specific peripheral cannabinoid receptor 2 (CB2) gene expression. Besides fibers, the compound was also found in all other flax tissues. It should be pointed out that the industrial process of fabric production does not affect CBD activity. The presented data suggest for the first time that flax products can be a source of biologically active cannabinoid-like compounds that are able to influence the cell immunological response. These findings might open up many new applications for medical flax products, especially for the fabric as a material for wound dressing with anti-inflammatory properties.
机译：亚麻是纤维，亚麻籽和油的重要来源。后两种产品的化合物已被广泛检查，并被证明具有许多有益健康的特性。在分析从先前产生的过量生产苯丙烷的转基因植物中提取的纤维时，发现了一种新的萜类化合物。该新化合物的UPLC分析的紫外光谱和保留时间表明它与大麻素样化合物（可能是大麻二酚（CBD））相似。通过在质谱分析中找到m / z 174. 1和231. 2的两个离子，可以证实这一点。化合物性质的进一步确认是基于生物学活性测定。发现该化合物影响小鼠和人成纤维细胞中炎症过程中涉及的基因的表达，并且可能来自大麻的CBD激活了特定的外周大麻素受体2（CB2）基因表达。除纤维外，在所有其他亚麻组织中也发现了该化合物。应该指出的是，织物生产的工业过程不会影响CBD的活性。提出的数据首次表明亚麻产品可以成为能够影响细胞免疫反应的具有生物活性的类大麻素化合物的来源。这些发现可能会为医用亚麻产品开辟许多新的应用领域，尤其是作为具有抗炎特性的伤口敷料材料的织物。

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