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首页> 外文期刊>Cellular Signalling >RTK SLAP DOWN: The emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling
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RTK SLAP DOWN: The emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling

机译：RTK SLAP DOWN：Src样衔接蛋白在受体酪氨酸激酶信号传导中起关键作用

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摘要

SLAP (Src like adaptor protein) contains adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains closely related in sequence to that of cytoplasmic Src family tyrosine kinases. Expressed most abundantly in the immune system, SLAP function has been predominantly studied in the context of lymphocyte signaling, where it functions in the Cbl dependent downregulation of antigen receptor signaling. However, accumulating evidence suggests that SLAP plays a role in the regulation of a broad range of membrane receptors including members of the receptor tyrosine kinase (RTK) family. In this review we highlight the role of SLAP in the ubiquitin dependent regulation of type III RTKs PDGFR, CSF-1R, KIT and Flt3, as well as Eph family RTKs. SLAP appears to bind activated type III and Eph RTKs via a conserved autophosphorylated juxtamembrane tyrosine motif in an SH2-dependent manner, suggesting that SLAP is important in regulating RTK signaling. (C) 2014 Elsevier Inc. All rights reserved.
机译：SLAP（Src样衔接蛋白）包含与细胞质Src家族酪氨酸激酶序列紧密相关的相邻Src同源性3（SH3）和Src同源性2（SH2）域。 SLAP功能在免疫系统中最丰富地表达，主要在淋巴细胞信号传导方面进行了研究，在淋巴细胞信号传导的Cbl依赖性下调中起作用。但是，越来越多的证据表明SLAP在调节广泛的膜受体（包括受体酪氨酸激酶（RTK）家族成员）中起作用。在这篇综述中，我们强调了SLAP在III型RTK PDGFR，CSF-1R，KIT和Flt3以及Eph家族RTK的泛素依赖性调节中的作用。 SLAP似乎通过保守的自磷酸化近膜酪氨酸基序以SH2依赖的方式结合激活的III型和Eph RTK，这表明SLAP在调节RTK信号传导中很重要。 （C）2014 Elsevier Inc.保留所有权利。

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