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首页> 外文期刊>Research in Microbiology >Diversity in the antibacterial potential of probiotic cultures Bacillus licheniformis MCC2514 and Bacillus licheniformis MCC2512
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Diversity in the antibacterial potential of probiotic cultures Bacillus licheniformis MCC2514 and Bacillus licheniformis MCC2512

机译：益生菌培养物地衣芽孢杆菌MCC2514和地衣芽孢杆菌MCC2512的抗菌潜能多样性

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摘要

The aim of the present study was to investigate the characteristic diversity and stability of antimicrobial compounds produced by two probiotic strains of Bacillus licheniformis (MCC2514 and MCC2512). Antimicrobial compounds from the two strains notably varied, related to stability and potency. The inhibitory spectrum of B. licheniformis MCC2512 was higher than MCC2514, but, related to the effect on Micrococcus luteus ATCC9341, MCC2514 (LD50 = 450 AU ml(-1)) was more potent than MCC2512 (LD50 = 750 AU ml(-1)). The compounds were thermo-resistant and stable at a wide range of pH and exhibited considerable resistance to digestive enzymes and bile salts (anionic biological detergents), contributing to their appropriate application in various food systems. The isolate B. licheniformis MCC2512 gave a positive response to Bacillus subtilis-based biosensors BSF2470 and BS168.BS2, confirming the mode of action on the cell wall and subtilin-type, respectively. For B. licheniformis MCC2514, the mode of action was characterized by constructing B. subtilis reporters that interfered in five major biosynthetic pathways, i.e., biosynthesis of DNA, RNA, protein, the cell wall and fatty acids. B. licheniformis MCC2514 responded to the yvgS reporter, indicating it as an RNA synthesis inhibitor. Overall, the investigation reveals variability of the antimicrobial compounds from B. licheniformis of different origins and for their possible application as biopreservative agents. (C) 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
机译：本研究的目的是研究由两种地衣芽孢杆菌益生菌菌株（MCC2514和MCC2512）产生的抗菌化合物的特征多样性和稳定性。来自两个菌株的抗微生物化合物显着变化，涉及稳定性和效力。地衣芽孢杆菌MCC2512的抑制谱高于MCC2514，但与黄l微球菌ATCC9341的影响有关，MCC2514（LD50 = 450 AU ml（-1））比MCC2512（LD50 = 750 AU ml（-1） ））。这些化合物具有耐热性，并在很宽的pH范围内稳定，并且对消化酶和胆汁盐（阴离子生物清洁剂）具有相当大的抵抗力，从而有助于它们在各种食品系统中的适当应用。分离的地衣芽孢杆菌MCC2512对基于枯草芽孢杆菌的生物传感器BSF2470和BS168.BS2产生了阳性反应，分别确认了对细胞壁和枯草杆菌素类型的作用方式。对于地衣芽孢杆菌MCC2514，其作用方式的特征在于构建了干扰五种主要生物合成途径即DNA，RNA，蛋白质，细胞壁和脂肪酸的生物合成的枯草芽孢杆菌报道基因。地衣芽孢杆菌MCC2514对yvgS报告基因有反应，表明它是一种RNA合成抑制剂。总的来说，研究揭示了来自不同来源的地衣芽孢杆菌的抗菌化合物的变异性，以及它们作为生物防腐剂的可能应用。 （C）2015年巴斯德研究所。由Elsevier Masson SAS发布。版权所有。

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