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首页> 外文期刊>Ophthalmology >Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery.
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Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery.

机译：溴莫尼定0.2％相对阿卡克隆定0.5％用于预防前段激光手术后眼内压升高。

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OBJECTIVE: To compare the efficacy of brimonidine 0.2% with apraclonidine 0.5% in preventing intraocular pressure (IOP) elevations after anterior segment laser surgery. DESIGN: Double-masked, randomized clinical trial. PARTICIPANTS: Sixty-six patients underwent either laser peripheral iridotomy, argon laser trabeculoplasty, or neodymium:yttrium-aluminum-garnet laser capsulotomy. INTERVENTION: Eyes received either one drop of brimonidine 0.2% or apraclonidine 0.5% before laser surgery. MAIN OUTCOME MEASURES: Intraocular pressure, heart rate, and blood pressure were measured before laser surgery and at 1 hour, 3 hours, 24 hours, and 1 week after laser surgery. RESULTS: Before the laser treatment, 33 patients (50.0%) received brimonidine 0.2% and 33 patients (50.0%) received apraclonidine 0.5%. Eight of 33 patients (24.2%) in the brimonidine-treated group and 9 of 33 patients (27.3%) in the apraclonidine group had postoperative IOP increases of 5 mmHg or more. This was not statistically different (P = 0.80). By the time of last follow-up examination, 3 of 33 patients (9.1%) in the brimonidine-treated group and 3 of 33 patients (9.1%) in the apraclonidine group had IOP increases of 10 mmHg or more. This was also not statistically different (P > or = 0.95). The mean IOP reduction from baseline in the brimonidine group (-2.8 +/- 2.8 mmHg) was not statistically different (P = 0.55) compared with the mean IOP reduction in the apraclonidine group (-3.6 +/- 3.3 mmHg). There were no statistically significant changes in mean heart rate or blood pressure in either group except for a slight reduction in diastolic blood pressure at 1 hour (P = 0.005) in the brimonidine group (-5.2 +/- 7.4 mmHg) compared with the apraclonidine group (-0.2 +/- 6.4 mmHg). There were no clinically significant side effects noted in either group. CONCLUSIONS: A single preoperative drop of brimonidine 0.2% is as effective as apraclonidine 0.5% in preventing IOP elevation immediately after anterior segment laser surgery.
机译：目的：比较0.2％的溴莫尼定和0.5％的apraclonidine在预防前段激光手术后眼内压（IOP）升高的疗效。设计：双掩蔽的随机临床试验。参加者：66例患者接受了激光周边虹膜切开术，氩气激光小梁成形术或钕：钇铝石榴石激光囊切开术。干预：在接受激光手术之前，眼睛接受一滴溴莫尼定0.2％或阿普拉可乐定0.5％。主要观察指标：在激光手术前以及激光手术后1小时，3小时，24小时和1周测量眼内压，心率和血压。结果：激光治疗前，33例（50.0％）接受了溴莫尼定0.2％的治疗，33例（50.0％）接受了阿普拉克隆定0.5％的治疗。溴莫尼定治疗组的33例患者中有8例（24.2％），阿帕克隆定组的33例患者中有9例（27.3％）术后眼压增加了5 mmHg或更高。这在统计学上没有差异（P = 0.80）。到最后一次随访检查时，溴莫尼定治疗组的33例患者中有3例（9.1％），阿普拉克隆定组的33例患者中有3例（9.1％）的IOP增加了10 mmHg或更高。这也没有统计学差异（P>或= 0.95）。溴莫尼定组的平均眼压降低（-2.8 +/- 2.8 mmHg）与阿普拉克力定组的平均眼压降低（-3.6 +/- 3.3 mmHg）无统计学差异（P = 0.55）。除溴莫尼定组（-5.2 +/- 7.4 mmHg）与阿普拉可乐定相比，溴莫尼定组在1小时时舒张压略有降低（P = 0.005）外，两组的平均心率或血压均无统计学上的显着变化组（-0.2 +/- 6.4 mmHg）。两组均未发现临床上明显的副作用。结论：术前单次滴入溴莫尼定0.2％与阿帕可乐定0.5％在预防眼前节激光手术后眼压升高方面同样有效。

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