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High-speed, high-resolution Fourier-domain optical coherence tomography system for retinal imaging in the 1060 nm wavelength region

机译:高速,高分辨率傅里叶域光学相干层析成像系统,用于1060 nm波长范围内的视网膜成像

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摘要

A high-speed (47,000 A-scans/s), ultrahigh axial resolution Fourier domain optical coherence tomography (OCT) system for retinal imaging at approx1060 nm, based on a 1024 pixel linear array, 47 kHz readout rate InGaAs camera is presented. When interfaced with a custom superluminescent diode ((lambda)_(c) velence 1020 nm, (DELTA)(lambda) velence 108 nm, P_(out)velence9 mW), the system provides 3.3 (mu)m axial OCT resolution at the surface of biological tissue, approx4.5 (mu)m in vivo in rat retina, approx5.7 (mu)m in vivo in human retina, and 110 dB sensitivity for 870 (mu)W incident power and 21 (mu)s integration time. Retinal tomograms acquired in vivo from a human volunteer and a rat animal model show clear visualization of all intraretinal layer and increased penetration into the choroid.
机译:提出了一种基于1024像素线性阵列,47 kHz读出速率的InGaAs相机的高速(47,000 A-扫描/秒)超高轴向分辨率傅里叶域光学相干断层扫描(OCT)系统,用于在大约1060 nm处进行视网膜成像。当与定制的超发光二极管(λ_c声速1020 nm,Δλ声光108 nm,P_(外)velence9 mW)连接时,该系统可提供3.3μm的轴向OCT分辨率生物组织表面,在大鼠视网膜中体内约4.5μm,在人视网膜中体内约5.7μm,对870μW入射功率和21μs积分的灵敏度为110 dB时间。从人类志愿者和大鼠动物模型体内获得的视网膜断层图显示了所有视网膜内层的清晰可视化,并增加了对脉络膜的穿透力。

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