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首页> 外文期刊>Oral oncology >Prognostic value of tissue polypeptide antigen in oral squamous cell carcinoma.
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Prognostic value of tissue polypeptide antigen in oral squamous cell carcinoma.

机译：组织多肽抗原在口腔鳞状细胞癌中的预后价值。

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Human oral cancer has a high risk of locoregional relapse which is difficult to diagnose early due to lack of prognostic markers. We and others have shown aberrant expression of cytokeratin (CK) 8 and 18 in human oral cancer. Aberrant supra-basal expression of CK19 has been shown earlier. In this study, our aim was to develop a non-invasive test for prognostication of human oral cancer. Immunoradiometric assay (IRMA) was used to measure the circulating levels of TPA in the sera of 80 oral cancer patients before surgery and seven days after surgery. Elevated serum TPA levels were noted in the post surgery samples of 28 out of the 50 patients for whom clinical follow-up was available, as compared to their pre-surgery samples. TPA levels in the pre-surgery serum samples of patients were significantly higher than levels in the sera of healthy controls (p=0.001). Elevated levels in patients correlated significantly with stage (p=0.02), development of recurrence (p<0.006), and impacted survival (p<0.033). IHC analysis showed statistically significant correlation between expression of CK8, 18 and 19 in surrounding uninvolved tissues of the tumour and post surgery elevated serum TPA levels (p<0.001). This suggests the possibility that CK fragments are released from the surrounding uninvolved tissues into the sera of patients after surgical removal of the tumour. Thus, our study indicates that TPA can be a useful tumour marker for the prediction of recurrence and poor prognosis in human oral cancer.
机译：人类口腔癌具有局部复发的高风险，由于缺乏预后标记，难以早期诊断。我们和其他人在人类口腔癌中显示了细胞角蛋白（CK）8和18的异常表达。 CK19的超基础表达异常已在早期显示。在这项研究中，我们的目的是开发一种用于人类口腔癌预后的非侵入性测试。免疫放射分析法（IRMA）用于测量80例口腔癌患者术前和术后7天血清中TPA的循环水平。与手术前样本相比，在可进行临床随访的50例患者中，有28例在手术后样本中发现血清TPA水平升高。患者术前血清样品中的TPA水平显着高于健康对照组血清中的TPA水平（p = 0.001）。患者水平升高与分期（p = 0.02），复发发展（p <0.006）和存活率显着相关（p <0.033）。 IHC分析显示，在肿瘤周围未累及的组织中CK8、18和19的表达与术后血清TPA水平升高之间存在统计学上的显着相关性（p <0.001）。这表明在手术切除肿瘤后，CK碎片可能从周围的未累及组织释放到患者的血清中。因此，我们的研究表明TPA可以作为预测人类口腔癌复发和不良预后的有用肿瘤标志物。

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