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首页> 外文期刊>Oral oncology >Synovial sarcoma involving skull base--a retrospective analysis of diagnosis and treatment of 21 cases in one institution.
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Synovial sarcoma involving skull base--a retrospective analysis of diagnosis and treatment of 21 cases in one institution.

机译：涉及颅底的滑膜肉瘤-一家机构21例诊断和治疗的回顾性分析。

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To retrospectively review the diagnosis and treatment outcomes of 21 diagnosed with synovial sarcoma (SS) extending to skull base region and identify prognostic factors for local recurrence and distant metastasis. The clinical and pathological records of 21 synovial sarcoma cases involving skull base treated at Department of Oral and Maxillofacial Surgery, Affiliated to Ninth People's Hospital, Shanghai Jiao Tong University, from 2003 to 2008 were reviewed. Parameters including clinical, radiographic, histological findings, and treatment modalities were analyzed. Prognostic factors influencing overall survival, local recurrence, and metastasis were identified. Categorical variables were compared between groups for local recurrence and distant metastasis by using 2-tailed Fisher exact test. The sample consisted of 8 males and 13 females with a median age of 23. 42.9% of cases showed skull base bone erosion with 9.5% of cases presenting intracranial tumor extension. 52.4% of cases died from recurrence or metastasis with a median survival time of 11 months. Orbital involvement, perineural and cranial invasion along with other factors were statistically significant for their impact on overall survival. Local recurrence was associated with tumors located in the infratemporal space (p=0.01), perineural invasion (p=0.001), pathological grade 3 (p=0.005), and tumor size >5 cm (p=0.008). The aggressive behavior of skull base SS and its close proximity to vital structures make the diagnosis and management a challenge. The study reported high local recurrence rates despite surgical and postoperative radiotherapy. Adjuvant chemotherapy did not seem to affect distant metastasis rates.
机译：回顾性分析21例滑膜肉瘤（SS）延伸至颅底区域的诊断和治疗结果，并确定局部复发和远处转移的预后因素。回顾了2003-2008年上海交通大学附属第九人民医院口腔颌面外科收治的21例滑膜肉瘤合并颅底的临床病理资料。分析了包括临床，影像学，组织学发现和治疗方式在内的参数。确定了影响总体生存，局部复发和转移的预后因素。通过使用2尾Fisher精确检验比较两组之间的局部复发和远处转移的分类变量。该样本由8位男性和13位女性组成，中位年龄为23岁。42.9％的病例显示颅底骨糜烂，而9.5％的病例表现为颅内肿瘤扩展。 52.4％的病例死于复发或转移，中位生存时间为11个月。眼眶受累，神经周围和颅骨受侵及其他因素对总体生存的影响在统计学上具有显着意义。局部复发与位于颞下间隙的肿瘤（p = 0.01），神经周围浸润（p = 0.001），病理等级3（p = 0.005）和肿瘤大小> 5 cm（p = 0.008）有关。颅底SS的侵略性行为及其与重要结构的接近使诊断和管理成为一项挑战。该研究报告尽管进行了手术和术后放疗，但局部复发率很高。辅助化疗似乎并未影响远处转移率。

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