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首页> 外文期刊>Oral oncology >Five-year follow-up study of saliva, mutans streptococci, lactobacilli and yeast counts in lymphoma patients.
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Five-year follow-up study of saliva, mutans streptococci, lactobacilli and yeast counts in lymphoma patients.

机译：对淋巴瘤患者的唾液，变形链球菌，乳杆菌和酵母菌计数进行了为期五年的随访研究。

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Twenty-two patients out of the 79 that were originally included were examined 5 years after beginning anticancer therapy for lymphomas. The patients' cumulative data on salivary flow rate, buffering capacity and acidogenic microbial counts were compared with respective data of 17 patients who died during the follow-up. Stimulated saliva samples had been taken at baseline and during the cytostatic treatment with combination chemotherapy, and 1 year and 5 years later. Chair-side kits were used at the hospital ward for the assessment of the study parameters. Mean saliva flow at baseline was 1.5 +/- 0.7 ml/min in the surviving group and 1.5 +/- 0.8 ml/min in the deceased. Salivary flow rates were not affected by the anticancer treatment and there was no statistically significant difference between the groups in this respect. A significant difference was observed between the groups in salivary buffering capacity values at baseline: only 32% of the survived had low buffering capacity in comparison to 69% of those who later died (P < 0.02). Buffering capacity values remained low in 50% of the surviving patients 5 years later. Higher mutans streptococci and lactobacilli counts were seen among the deceased than in the survived patients but mutans streptococci decreased significantly in both groups after the start of the anticancer therapy (P < 0.05). The number of positive yeast counts increased consistently during the chemotherapy in both groups, being higher in the survived when compared with the deceased patients. Yeast counts remained positive 5 years later in 73% of the survived patients, while the mean mutans streptococci and lactobacilli counts decreased below baseline values. The results showed that persistently high salivary microbial counts and low buffering capacity may be linked with poor prognosis.
机译：开始对淋巴瘤进行抗癌治疗后5年，对最初纳入的79名患者中的22名患者进行了检查。将患者的唾液流量，缓冲能力和产酸微生物计数的累积数据与随访期间死亡的17例患者的各自数据进行比较。在基线期和联合化疗的细胞抑制治疗期间以及1年和5年后，采集刺激唾液样本。医院病房使用椅子旁的工具包评估研究参数。存活组的基线平均唾液流量为1.5 +/- 0.7 ml / min，死者为1.5 +/- 0.8 ml / min。唾液流速不受抗癌治疗的影响，在这方面两组之间在统计学上没有显着差异。基线时，唾液的缓冲能力值之间存在显着差异：仅32％的存活者缓冲能力低，而后来死亡者中只有69％（P <0.02）。 5年后存活的患者中有50％的缓冲能力值仍然很低。死者中的变形链球菌和乳酸菌计数高于存活患者，但在开始抗癌治疗后，两组中的变形链球菌均显着下降（P <0.05）。两组化疗期间酵母阳性酵母数均持续增加，与死者相比，存活率更高。 5年后，存活的患者中73％的酵母菌计数保持阳性，而平均变形链球菌和乳酸菌计数降至基线值以下。结果表明，唾液中微生物数量持续高和缓冲能力低可能与不良预后有关。

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