...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oral oncology >Treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neck
【24h】

Treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neck

机译：头颈部腺样囊性癌的治疗结果和预后特征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Surgery is the main treatment modality for adenoid cystic carcinoma (ACC) originated from the head and neck. However, the extensive local infiltrative and perineural spread related to this malignancy often cause difficulty to achieve high tumor control. The aim of this study is to evaluate the efficacy of postoperative radiotherapy (RT) in ACC, and to identify prognostic variables associated with treatment outcomes. A retrospective review of 101 patients diagnosed with ACC in the head and neck region was performed. T stage distribution was T1, 25; T2, 35; T3, 18; and T4, 23 patients. All patients were grouped into two arms: surgery alone or combined with postoperative radiotherapy. The 5-year local-regional control (LRC), overall survival (OS) and disease-free survival (DFS) rates for all the patients were 70.5%, 91.7% and 63.2%, respectively. On univariant analysis, postoperative radiotherapy did improve the 5-year LRC and DFS compared to surgery alone (81.0% vs. 53.4%, p = 0.0003 and 71.3% vs. 50.0%, p = 0.0052, respectively). And patients with T1-T2 lesions achieved better treatment outcomes, whereas stage T3-T4 was associated with high local failure and poor disease-free survival. Furthermore, multivariate analysis revealed that the addition of radiotherapy and early lesions were both favorite predictors for local control and survival rates. The prognosis for ACC of the head and neck was excellent. Surgery combined with postoperative radiotherapy significantly reduced the local failure, and further improved disease-free survival. Nevertheless, the relatively high distant metastasis was an obstacle of curing the ACC patients.
机译：手术是起源于头颈部的腺样囊性癌（ACC）的主要治疗方式。然而，与该恶性肿瘤相关的广泛的局部浸润和神经周围扩散通常导致难以实现高度的肿瘤控制。这项研究的目的是评估ACC术后放射治疗（RT）的疗效，并确定与治疗结果相关的预后变量。回顾性分析了101例被诊断为头颈部区域ACC的患者。 T阶段分布为T1，25; T2，35; T3，18; T4 23例所有患者分为两部分：单独手术或联合放疗。所有患者的5年局部控制率（LRC），总生存率（OS）和无病生存率（DFS）分别为70.5％，91.7％和63.2％。根据单因素分析，与单独手术相比，术后放疗确实改善了5年期LRC和DFS（分别为81.0％比53.4％，p = 0.0003和71.3％vs. 50.0％，p = 0.0052）。 T1-T2病变患者获得更好的治疗效果，而T3-T4期与局部失败率高和无疾病生存期相关。此外，多变量分析显示，放疗和早期病变都是局部控制和生存率的首选预测指标。头颈部ACC的预后极好。手术结合术后放疗可显着减少局部衰竭，并进一步改善无病生存期。然而，相对较高的远处转移是治愈ACC患者的障碍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号