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首页> 外文期刊>Oral oncology >Microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in Malaysian population.
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Microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in Malaysian population.

机译：马来西亚人群口腔鳞状细胞癌中的微卫星不稳定性和杂合性丧失。

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Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been documented as important events in oral squamous cell carcinoma (OSCC). Five microsatellite markers D3S192, D3S966, D3S647, D3S1228 and D3S659 were selected on chromosome 3p because of high frequency of alterations reported in head and neck squamous cell carcinoma and the involvement of von Hippel Lindau (VHL) at 3p25-26 and the fragile histidine triad (FHIT) at 3p14.2 genes proven in many tumour types. A total of 50 archival tissue samples of OSCC and corresponding normal samples were analyzed for LOH and MSI status. The overall LOH for the markers selected on 3p was 56 out of 189 informative cases (29.6%). The most frequent LOH was identified for the marker D3S966 which was 18/42 (42.8%) of informative cases suggesting the presence of putative tumour suppressor genes (TSGs) in this loci. In this study, high frequency of microsatellite instability was found in D3S966 which was 28.6% of informative cases; this reveals the possibility of mutations of MMR genes in this region. Frequent microsatellite alterations (MA) were observed in 3 markers D3S966 (71.4%), D3S1228 (56.7%) and D3S192 (41.0%). There was no significant association between LOH with gender, tumour stages and differentiation grades. However, there was a significant association between tumour stage and differentiation grades with MSI status in OSCC in Malaysian population with p values of 0.002 and 0.035, respectively. There was also a significant association between MA and differentiation grades (p=0.041).
机译：杂合性丧失（LOH）和微卫星不稳定性（MSI）已被记录为口腔鳞状细胞癌（OSCC）的重要事件。在3p染色体上选择了5个微卫星标记D3S192，D3S966，D3S647，D3S1228和D3S659，原因是头颈部鳞状细胞癌中报道的改变频率很高，并且von Hippel Lindau（VHL）参与了3p25-26以及脆弱的组氨酸三联体（FHIT）3p14.2基因已在许多肿瘤类型中得到证实。总共分析了50个OSCC存档组织样本和相应的正常样本的LOH和MSI状态。在189例病例中，选择3p标记的总体LOH为56（29.6％）。鉴定到标记物D3S966的频率最高，占资料丰富病例的18/42（42.8％），表明在该基因座中存在推定的肿瘤抑制基因（TSG）。在这项研究中，D3S966中发现微卫星不稳定的频率很高，占情报事件的28.6％;这揭示了该区域MMR基因突变的可能性。在3个标记D3S966（71.4％），D3S1228（56.7％）和D3S192（41.0％）中观察到频繁的微卫星改变（MA）。 LOH与性别，肿瘤分期和分化程度之间无显着关联。然而，在马来西亚人群中，OSCC的肿瘤分期和分化程度与MSI状态之间存在显着相关性，p值分别为0.002和0.035。 MA与分化等级之间也存在显着关联（p = 0.041）。

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