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首页> 外文期刊>Osteoarthritis and cartilage >A study of the prevalence and associations of subchondral bone marrow lesions in the knees of healthy, middle-aged women.
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A study of the prevalence and associations of subchondral bone marrow lesions in the knees of healthy, middle-aged women.

机译：健康中年女性膝盖软骨下骨髓病变的发生率和相关性研究。

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OBJECTIVE: Bone marrow lesions (BMLs) have been shown to be associated with pain and progression of knee osteoarthritis (OA) in those with disease. The natural history of BMLs in a healthy population and their role in the pathogenesis of OA are unknown. The aim of this study was to determine the risk factors for BMLs in healthy subjects and the association of BMLs with knee structure. METHODS: One hundred and seventy-six healthy, adult women with no history of knee injury, or clinical knee OA had magnetic resonance imaging performed on their dominant knee to assess BMLs, tibiofemoral cartilage defects, tibial cartilage volume and bone area. RESULTS: Thirteen percent of subjects had knee BMLs. The prevalence was higher in the medial tibiofemoral compartment. There was a significant positive association between BMLs and cartilage defects after adjusting for the potential risk factors: age, height, weight and cartilage volume [odds ratio (OR) 1.78 (95% confidence interval [CI] 1.12, 2.82), P=0.01]. BML was positively associated with tibial plateau bone area in the lateral compartment [OR 1.67 (95% CI 1.02, 2.71), P=0.04]. There was no significant association between BMLs and cartilage volume. Independent risk factors for BMLs after adjustment were increasing height [OR 1.18 (95% CI 1.02, 1.36), P=0.02 for lateral compartment] and weight [OR 1.04 (95% CI 1.01, 1.08), P=0.005 for total knee]. CONCLUSION: These data support that BMLs are present in a similar distribution to tibiofemoral knee OA. Their presence is associated with risk factors (height and weight) for knee OA, and the early structural changes of knee OA in subjects without knee pain and thus no clinical disease. Longitudinal studies will clarify whether BMLs relate to the pathogenesis of clinical knee OA.
机译：目的：已证明在患有疾病的患者中，骨髓损伤（BML）与疼痛和膝骨关节炎（OA）的进展有关。健康人群中BML的自然史及其在OA发病机理中的作用尚不清楚。这项研究的目的是确定健康受试者中BML的危险因素以及BML与膝盖结构的关系。方法：176例无膝关节损伤史或临床膝关节炎的健康成年女性，其优势膝关节进行了磁共振成像，以评估BML，胫股软骨缺损，胫骨软骨体积和骨面积。结果：13％的受试者患有膝关节BML。胫股内侧腔的患病率较高。校正潜在的危险因素：年龄，身高，体重和软骨体积后，BML与软骨缺损之间存在显着的正相关性[比​​值比（OR）1.78（95％置信区间[CI] 1.12，2.82），P = 0.01 ]。 BML与外侧腔室的胫骨平台骨面积呈正相关[OR 1.67（95％CI 1.02，2.71），P = 0.04]。 BML和软骨量之间没有显着关联。调整后BML的独立危险因素为身高[OR 1.18（95％CI 1.02，1.36），外侧室P = 0.02]和体重[OR 1.04（95％CI 1.01，1.08），P = 0.005（全膝关节）]。 。结论：这些数据支持BMLs以与胫股膝OA相似的分布存在。它们的存在与膝盖OA的危险因素（身高和体重）有关，并且与没有膝盖疼痛且因此没有临床疾病的受试者的OA早期结构变化有关。纵向研究将阐明BML是否与临床膝骨关节炎的发病机制有关。

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