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首页> 外文期刊>Osteoarthritis and cartilage >Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK).
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Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK).

机译：一群患有骨关节炎（CHECK）早期迹象的患者的皮肤和尿液中的戊糖苷与关节损伤微弱相关。

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OBJECTIVES: Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches such as analyzing skin and urine are needed to study the role of cartilage AGE levels in OA. METHODS: Paired human skin and cartilage samples were obtained post mortem. Paired skin and urine samples were obtained from the CHECK cohort (early OA patients). Pentosidine levels were measured by high-performance liquid chromatography (HPLC). As marker of cumulative cartilage damage X-rays of both knees and hips were scored. Urinary CTXII (uCTXII) levels were measured, to assess current cartilage breakdown. RESULTS: Cartilage and skin pentosidine correlate well (R=0.473, P=0.05). Skin pentosidine was higher in mild (summed (Kellgren & Lawrence K&L) over four large joints >/=4) compared to no (summed K&L
机译：目的：与年龄有关的关节软骨变化可能在骨关节炎（OA）的病因中起作用。与年龄相关的主要软骨变化之一是晚期糖基化终产物（AGEs）的积累。由于患者尚不容易获得软骨组织用于研究AGE水平，因此需要其他方法（例如分析皮肤和尿液）来研究软骨AGE水平在OA中的作用。方法：取死后配对的人类皮肤和软骨样品。配对的皮肤和尿液样本来自CHECK队列（早期OA患者）。戊糖苷水平通过高效液相色谱（HPLC）测量。作为累积软骨损伤的标志，对膝盖和臀部的X射线进行评分。测量了尿中的CTXII（uCTXII）水平，以评估当前的软骨破坏情况。结果：软骨和皮肤戊糖苷的相关性很好（R = 0.473，P = 0.05）。与没有（总K＆L

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