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首页> 外文期刊>Online journal of veterinary research OJVR >Effect of inactivated Neospora caninum tachyzoite vaccine on immune markers and transplacental transmission in pregnant BALB/c mice.
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Effect of inactivated Neospora caninum tachyzoite vaccine on immune markers and transplacental transmission in pregnant BALB/c mice.

机译：灭活犬新孢子虫速殖子疫苗对妊娠BALB / c小鼠免疫标记和胎盘传播的影响。

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Abdeyazdan A, Namavari M., Effect of inactivated Neospora caninum tachyzoite vaccine on immune markers and transplacental transmission in pregnant BALB/c mice, Onl J Vet Res., 19(9): 689-697, 2015. Neospora caninum causes abortion in cattle. Neosporavaccines can minimize and control the infection in mice but not in cattle. Eight mice were subcutaneously injected 3070% water-in-Montanide ISA 773 oil emulsions with 1 x 10~6 inactivated tachyzoites. After immunization and mating, pregnant mice were challenged with live 2x10~6 tachyzoites. Parasites present in the brain and tissues of the pups and adult mice were detected/assessed by PCR, serological and footpad tests. Vaccinated adults or pups showed no symptoms of neosporosis until euthanasia whereasun-vaccinated oil controls (8) showed severe weight loss and posterior limb paralysis. Four of eight plugged mice in the vaccinated group gave birth with lower pregnancy rate compared with controls. Antibody against N. caninum was detected in all mice vaccinated with whole killed tachyzoite compared with mice in control group. Vaccinated mice showed significant footpad swelling whereas controls did not and parasite DNA was detected in brain tissue of all controls but none in vaccinated mice.
机译：Abdeyazdan A，Namavari M.，灭活新孢子虫速殖子疫苗对孕妇BALB / c小鼠免疫标记和胎盘传播的影响，Onl J Vet Res。，19（9）：689-697，2015.新孢子虫导致牛流产。新孢子菌疫苗可以最大程度地减少和控制小鼠的感染，但不能抑制牛的感染。八只小鼠被皮下注射3070％的Montanide ISA 773水包油乳剂，其中含有1×10〜6个灭活速殖子。免疫和交配后，用活的2x10〜6速殖子攻击妊娠小鼠。通过PCR，血清学和脚垫测试检测/评估幼犬和成年小鼠的大脑和组织中存在的寄生虫。接种疫苗的成年或幼犬在安乐死之前没有新孢子虫病的症状，而未接种疫苗的油对照（8）显示出严重的体重减轻和后肢麻痹。接种组的八只经灌肠的小鼠中有四只的出生率比对照组低。与对照组相比，在接种了全灭活速殖子的所有小鼠中都检测到了犬新孢子虫的抗体。接种疫苗的小鼠表现出明显的足垫肿胀，而对照没有，并且在所有对照的脑组织中均检测到寄生虫DNA，而接种疫苗的小鼠中没有检测到。

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