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首页> 外文期刊>Schizophrenia research >Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders.
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Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders.

机译：精神分裂症和情绪障碍的前额叶皮层神经元少突胶质细胞缺乏。

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OBJECTIVE: A deficit of oligodendrocytes has been reported in the prefrontal cortex (PFC) in schizophrenia (SCH), bipolar disorder (BPD) and major depression (MDD). Also, a decreased size of pyramidal neurons has been detected in layer III in SCH and in mood disorders. Since oligodendrocytes have a trophic influence on neurons, reduced neuronal size reported in these disorders might be associated with the deficit in subpopulation of perineuronal oligodendrocytes. We hypothesized that deficit of perineuronal oligodendrocytes might occur in SCH and mood disorders. METHOD: We estimated the number of oligodendroglial satellites of pyramidal neurons and the size of pyramidal neurons in layer III (Brodmann's area 9) in Nissl stained sections in SCH, BPD, MDD and normal controls. The Stanley Foundation Neuropathology Consortium brain collection consisted of 15 cases in each of four groups was used. RESULTS: We detected a prominent and significant reduction in the number of perineuronal oligodendrocytes in thesublayers IIIa, IIIb and IIIc in SCH, BPD and MDD as compared to controls. The BPD group differed significantly from SCH group and from MDD group. There were no significant differences in somal sizes of pyramidal neurons in the sublayers IIIa, IIIb, IIIc between each of the psychiatric groups and the control group. Only BPD group showed significantly smaller neuronal size in sublayer IIIc as compared to controls. CONCLUSIONS: Our data provide evidence for a deficit of perineuronal oligodendrocytes in severe mental disorders that may play a key role in the pathophysiology of SCH, BPD and MDD.
机译：目的：精神分裂症（SCH），双相情感障碍（BPD）和重度抑郁症（MDD）的前额叶皮层（PFC）中少突胶质细胞缺乏。同样，在SCH和情绪障碍的第三层中已检测到锥体神经元大小的减少。由于少突胶质细胞对神经元有营养作用，因此这些疾病中报告的神经元大小减少可能与神经周围少突胶质细胞亚群的缺乏有关。我们假设在SCH和情绪障碍中可能发生神经周围少突胶质细胞的缺乏。方法：我们估计了SCH，BPD，MDD和正常对照的Nissl染色切片中第三层（Brodmann氏区9）的锥体神经元少突神经胶质卫星的数量和锥体神经元的大小。斯坦利基金会神经病理学联合会的大脑集合包括四组中的每组15例。结果：与对照组相比，我们发现SCH，BPD和MDD中亚层IIIa，IIIb和IIIc的神经胶质少突胶质细胞数量显着减少。 BPD组与SCH组和MDD组明显不同。在每个精神病组和对照组之间，亚层IIIa，IIIb，IIIc的锥体神经元体大小没有显着差异。与对照组相比，只有BPD组在IIIc子层中显示出明显较小的神经元大小。结论：我们的数据为严重精神障碍中神经周围神经少突胶质细胞的缺乏提供了证据，这可能在SCH，BPD和MDD的病理生理中起关键作用。

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