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首页> 外文期刊>Schizophrenia research >Predictors of recovery from psychosis Analyses of clinical and social factors associated with recovery among patients with first-episode psychosis after 5 years.
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Predictors of recovery from psychosis Analyses of clinical and social factors associated with recovery among patients with first-episode psychosis after 5 years.

机译：精神病康复的预测因素与5年后首发精神病患者康复相关的临床和社会因素分析。

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INTRODUCTION: This paper aims to investigate the predictors of good outcome after first-episode non-affective psychosis and the clinical and social trajectories of those that recover. METHODS: A cohort of 255 patients with first-episode non-affective psychosis was interviewed 5 years after first diagnosis and treatment. Recovery was defined as working or studying, having a GAF-function score of 60 or above, having remission of negative and psychotic symptoms, and not living in a supported housing facility or being hospitalized during the last 2 years before the five-year follow-up interview. RESULTS: A total of 40 (15.7%) were found to be recovered, and 76 (29.8%) had a job or were studying after 5 years. Of those working, as many as 20 still had psychotic symptoms. Also notable is that out of the 40 recovered, less than half were recovered after 2 years. Recovery after 5 years was predicted by female sex (OR 2.4, 95% CI 1.0-5.8), higher age (OR 0.91, 95% CI 0.83-0.99), pre-morbid social adaptation (OR 0.72, 95% CI 0.56-0.93), growing up with both parents (OR 2.6, 95% CI 1.0-6.8) and low level of negative symptoms (OR 0.51, 95% CI 0.33 to 0.77) at baseline. DISCUSSION: Our findings suggest that a stable social life with normal social functioning has a predictive value for good outcome. These measures might be influenced by negative symptoms, but in the multivariate analysis with negative symptoms included they have an independent effect. Also our findings suggest that, after first-episode psychosis, some patients can still experience psychotic symptoms, but have a job and a fairly stable life.
机译：引言：本文旨在研究首次发作非情感性精神病后良好结局的预测因素，以及康复者的临床和社会轨迹。方法：对首次诊断和治疗5年后的255例首次发作的非情感性精神病患者进行了访谈。恢复是指工作或学习，GAF功能得分为60或以上，具有消极和精神病症状，并且在五年随访之前的最近2年内未住在有支持的住房设施中或未住院，面试。结果：共发现40人（15.7％），5年后有工作或正在研究中的人有76人（29.8％）。在那些工作的人中，仍有多达20人患有精神病症状。同样值得注意的是，在回收的40件产品中，不到2年后回收的产品不到一半。女性（OR 2.4，95％CI 1.0-5.8），较高年龄（OR 0.91，95％CI 0.83-0.99），病前社会适应（OR 0.72，95％CI 0.56-0.93）预测5年后会恢复），在父母双方（OR 2.6，95％CI 1.0-6.8）和低水平的阴性症状（OR 0.51，95％CI 0.33至0.77）的陪伴下成长。讨论：我们的发现表明，稳定的社交生活和正常的社交功能对于良好的结局具有预测价值。这些措施可能会受到负面症状的影响，但是在包含负面症状的多变量分析中，它们具有独立的作用。我们的研究结果还表明，在首次发作的精神病之后，一些患者仍会出现精神病症状，但工作和生活相当稳定。

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