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Prolactin and Psychopathology in Schizophrenia: A Literature Review and Reappraisal

机译：精神分裂症的催乳素与精神病理学：文献复习与重新评估

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摘要

Secretion of the anterior pituitary hormone prolactin can be significantly increased by antipsychotic drugs, leading to a range of adverse effects in patients with schizophrenia. However, there is evidence from a variety of studies that prolactin may also be related to symptom profile and treatment response in these patients, and recent work has identified variations in prolactin secretion even in drug-free patients. In this paper, a selective review of all relevant studies pertaining to prolactin and schizophrenia, including challenge and provocation studies, is presented. The implications of this work are discussed critically. A tentative model, which synthesizes these findings and argues for a significant role for prolactin in the development of schizophrenia, is outlined.
机译：抗精神病药可显着增加垂体前叶催乳激素的分泌，从而导致精神分裂症患者产生一系列不良反应。然而，各种研究表明，催乳素也可能与这些患者的症状特征和治疗反应有关，并且最近的研究发现催乳素分泌的变化，甚至在无药物患者中也是如此。本文对与催乳素和精神分裂症有关的所有相关研究（包括挑战研究和挑衅研究）进行了选择性综述。这项工作的意义进行了严格的讨论。概述了一个试验模型，该模型综合了这些发现，并认为催乳素在精神分裂症的发生中具有重要作用。

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